SCHEMBL20813282

SCHEMBL20813282

Cc1ccc(-c2ccc3c(F)c(C#CC(F)(F)F)c(F)cc3c2)c(F)c1

nearest known ligand 0.33

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
HSD17B1 P14061 1/20 0.33
HSD17B2 P37059 1/20 0.33
ESR1 P03372 2/20 0.32
ESR2 Q92731 2/20 0.32
PDE9A O76083 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20803158 0.94 HSD17B1 (0.30) HSD17B1HSD17B2
SCHEMBL20813653 0.93 CYP11B1 (0.33) HSD17B1HSD17B2ESR1ESR2
SCHEMBL20813648 0.92 PDE9A (0.32) PDE9A
SCHEMBL20813702 0.90 GRM5 (0.32) HSD17B1HSD17B2
SCHEMBL20813717 0.87 ALOX5AP (0.31)
SCHEMBL20813674 0.87 CYP11B1 (0.31)
SCHEMBL20813662 0.86 HDAC1 (0.32)
SCHEMBL20803259 0.85 HSD17B1 (0.33) HSD17B1HSD17B2ESR1ESR2
SCHEMBL20813975 0.85
SCHEMBL20803159 0.84 HSD17B1 (0.34) HSD17B1HSD17B2ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3453697-A1 COMPOUND HAVING NAPHTHALENE RING, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT JNC Corporation (JP) 2019-03-13 EP disclosed