Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20816003 | 1.00 | LMNA (0.50) | LMNAHIF1AGALR3ADRB2ADRB1 | |
| SCHEMBL3227928 | 0.82 | AOC3 (0.40) | LMNAHIF1AADRB2ADRB1HTR1A | |
| SCHEMBL3931230 | 0.82 | LMNA (0.57) | LMNAHIF1AGALR3ADRB2ADRB1 | |
| SCHEMBL3931227 | 0.82 | LMNA (0.57) | LMNAHIF1AGALR3ADRB2ADRB1 | |
| SCHEMBL10178568 | 0.81 | HDAC4 (0.47) | GAAFFAR1 | |
| SCHEMBL24015105 | 0.80 | LMNA (0.55) | LMNAHIF1AGALR3ADRB2ADRB1 | |
| SCHEMBL11595350 | 0.79 | LMNA (0.70) | LMNAHIF1AGALR3ADRB2ADRB1 | |
| SCHEMBL27536091 | 0.79 | LMNA (0.53) | LMNAHIF1AGALR3ADRB2ADRB1 | |
| SCHEMBL10154607 | 0.78 | HDAC4 (0.46) | TSHRKDM4E | |
| SCHEMBL20738611 | 0.76 | ABCB11 (0.46) | FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10565015-B2 | Spiroketal-based C2-symmetric scaffold for asymmetric catalysis | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-02-18 | — | — | US | disclosed |
| US-20190084995-A1 | Spiroketal-Based C2-Symmetric Scaffold For Asymmetric Catalysis | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2019-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10565015-B2 | Spiroketal-based C2-symmetric scaffold for asymmetric catalysis | PKD2, OPA1, PKD1 | LMNA 2772/4885HIF1A 2277/4885GALR3 1906/4885 |
| US-20190084995-A1 | Spiroketal-Based C2-Symmetric Scaffold For Asymmetric Catalysis | PKD2, OPA1, PKD1 | LMNA 2772/4885HIF1A 2277/4885GALR3 1906/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.