Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 13/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 13/20 | 0.62 |
| ▸ | CLK4 | Q9HAZ1 | 11/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.56 |
| ▸ | KMO | O15229 | 1/20 | 0.55 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | BCR | P11274 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20816281 | 0.81 | CYP1A2 (0.62) | CYP1A2CYP3A4CLK4HSD17B10CYP2D6 | |
| SCHEMBL12907691 | 0.80 | CYP3A4 (0.58) | CYP1A2CYP3A4CLK4HSD17B10CYP2D6 | |
| SCHEMBL20816285 | 0.80 | ABL1 (0.55) | CYP1A2CYP3A4CLK4HSD17B10CYP2D6 | |
| SCHEMBL19905207 | 0.79 | CYP1A2 (0.51) | CYP1A2CYP3A4CLK4HSD17B10CYP2D6 | |
| SCHEMBL6844957 | 0.78 | CYP2A6 (0.62) | CYP1A2CYP3A4CLK4HSD17B10CYP2D6 | |
| SCHEMBL18905235 | 0.78 | KMO (0.68) | CYP1A2CYP3A4CLK4HSD17B10CYP2D6 | |
| SCHEMBL30200067 | 0.77 | CYP1A2 (0.54) | CYP1A2CYP3A4CLK4HSD17B10CYP2D6 | |
| SCHEMBL3565337 | 0.76 | ABL1 (0.66) | CYP1A2CYP3A4CLK4HSD17B10CYP2D6 | |
| SCHEMBL28152165 | 0.75 | HSP90AA1 (0.54) | MEN1KMT2ATSHRCYP2A6PIM1 | |
| SCHEMBL24151512 | 0.75 | KMO (0.59) | CYP1A2CYP3A4CLK4HSD17B10CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10624897-B2 | Chlorobenzene substituted azaaryl compounds | TAIPEI MEDICAL UNIVERSITY (TW) | 2020-04-21 | — | — | US | disclosed |
| US-10624897-B2 | Chlorobenzene substituted azaaryl compounds | TAIPEI MEDICAL UNIVERSITY (TW) | 2020-04-21 | — | — | US | disclosed |
| US-20190083499-A1 | CHLOROBENZENE SUBSTITUTED AZAARYL COMPOUNDS | TAIPEI MEDICAL UNIVERSITY (TW) | 2019-03-21 | — | — | US | disclosed |
| US-20190083499-A1 | CHLOROBENZENE SUBSTITUTED AZAARYL COMPOUNDS | TAIPEI MEDICAL UNIVERSITY (TW) | 2019-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10624897-B2 | Chlorobenzene substituted azaaryl compounds | MKI67, CTCF, CDKN1A | CYP1A2 95/4885CYP3A4 181/4885CLK4 2558/4885 |
| US-20190083499-A1 | CHLOROBENZENE SUBSTITUTED AZAARYL COMPOUNDS | MKI67, CTCF, CDKN1A | CYP1A2 95/4885CYP3A4 181/4885CLK4 2558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.