Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.58 |
| ▸ | GAA | P10253 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4676031 | 0.79 | GAA (0.61) | ALDH1A1GAAHPGDL3MBTL1SMN1; SMN2 | |
| SCHEMBL11795775 | 0.76 | GAA (0.67) | ALDH1A1GAAHPGDL3MBTL1LMNA | |
| SCHEMBL20819243 | 0.75 | GAA (0.56) | ALDH1A1GAAHPGDL3MBTL1SMN1; SMN2 | |
| SCHEMBL6251239 | 0.74 | RAB9A (0.64) | ALDH1A1GAAHPGDSMN1; SMN2LMNA | |
| SCHEMBL11927276 | 0.74 | GAA (0.73) | ALDH1A1GAAHPGDL3MBTL1SMN1; SMN2 | |
| SCHEMBL1686848 | 0.74 | GAA (1.00) | ALDH1A1GAAHPGDL3MBTL1LMNA | |
| SCHEMBL10402042 | 0.74 | GAA (0.73) | ALDH1A1GAAHPGDL3MBTL1LMNA | |
| SCHEMBL8957661 | 0.73 | ALDH1A1 (0.68) | ALDH1A1GAAHPGDL3MBTL1SMN1; SMN2 | |
| SCHEMBL999575 | 0.73 | ALDH1A1 (1.00) | ALDH1A1GAAHPGDL3MBTL1SMN1; SMN2 | |
| SCHEMBL8957668 | 0.73 | ALDH1A1 (0.68) | ALDH1A1GAAHPGDL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200308165-A1 | Compounds as Ras Inhibitors and Use Thereof | D. E. SHAW RESEARCH, LLC | 2020-10-01 | — | — | US | disclosed |
| US-20200308165-A1 | Compounds as Ras Inhibitors and Use Thereof | D. E. SHAW RESEARCH, LLC | 2020-10-01 | — | — | US | disclosed |
| EP-3681499-A1 | COMPOUNDS AS RAS INHIBITORS AND USE THEREOF | D.E. Shaw Research, LLC (US) | 2020-07-22 | — | — | EP | disclosed |
| WO-2019055540-A1 | COMPOUNDS AS RAS INHIBITORS AND USE THEREOF | D.E. SHAW RESEARCH, LLC (US) | 2019-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200308165-A1 | Compounds as Ras Inhibitors and Use Thereof | KRAS, NRAS, HRAS | ALDH1A1 2215/4885GAA 598/4885HPGD 2319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.