Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 9/20 | 0.59 |
| ▸ | IKZF3 | Q9UKT9 | 5/20 | 0.55 |
| ▸ | TNF | P01375 | 4/20 | 0.55 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.55 |
| ▸ | BRD4 | O60885 | 2/20 | 0.55 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.55 |
| ▸ | IL1B | P01584 | 1/20 | 0.55 |
| ▸ | MAP1LC3B | Q9GZQ8 | 6/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.50 |
| ▸ | IKZF2 | Q9UKS7 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25036780 | 0.91 | CRBN (0.57) | CRBNIKZF3TNFIKZF1BRD4 | |
| SCHEMBL19453154 | 0.91 | CRBN (0.58) | CRBNIKZF3TNFIKZF1BRD4 | |
| SCHEMBL20913604 | 0.89 | CRBN (0.56) | CRBNIKZF3TNFIKZF1BRD4 | |
| SCHEMBL31415716 | 0.89 | CRBN (0.56) | CRBNIKZF3TNFIKZF1BRD4 | |
| SCHEMBL25036210 | 0.89 | CRBN (0.54) | CRBNIKZF3TNFIKZF1BRD4 | |
| SCHEMBL21069441 | 0.86 | CRBN (0.52) | CRBNIKZF3TNFIKZF1BRD4 | |
| SCHEMBL25036778 | 0.86 | CRBN (0.51) | CRBNIKZF3TNFIKZF1BRD4 | |
| SCHEMBL20819230 | 0.85 | CRBN (0.60) | CRBNIKZF3TNFIKZF1DDB1 | |
| SCHEMBL29424175 | 0.85 | CRBN (0.60) | CRBNIKZF3TNFIKZF1DDB1 | |
| SCHEMBL31548718 | 0.84 | CRBN (0.65) | CRBNIKZF3TNFIKZF1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11267822-B2 | BET bromodomain protein degraders with cleavable linkers | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2022-03-08 | — | — | US | disclosed |
| US-20200277305-A1 | BET Bromodomain Protein Degraders with Cleavable Linkers | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-09-03 | — | — | US | disclosed |
| US-20200277305-A1 | BET Bromodomain Protein Degraders with Cleavable Linkers | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-09-03 | — | — | US | disclosed |
| WO-2019055444-A1 | BET BROMODOMAIN PROTEIN DEGRADERS WITH CLEAVABLE LINKERS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-03-21 | — | — | WO | disclosed |
| WO-2019055444-A1 | BET BROMODOMAIN PROTEIN DEGRADERS WITH CLEAVABLE LINKERS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200277305-A1 | BET Bromodomain Protein Degraders with Cleavable Linkers | BRD4, BET1, BRWD1 | CRBN 142/4885IKZF3 453/4885TNF 4467/4885 |
| US-11267822-B2 | BET bromodomain protein degraders with cleavable linkers | BRD4, BET1, BRWD1 | CRBN 142/4885IKZF3 453/4885TNF 4467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.