Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 9/20 | 0.41 |
| ▸ | TOP2B | Q02880 | 9/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.35 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2081924 | 1.00 | TOP2A (0.41) | TOP2ATOP2BKDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL2082116 | 0.87 | TOP2A (0.42) | TOP2ATOP2BKDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL2082114 | 0.87 | TOP2A (0.42) | TOP2ATOP2BKDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL27564237 | 0.87 | TOP2A (0.42) | TOP2ATOP2BKDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL2081036 | 0.86 | STAT3 (0.46) | KDM4ESMN1; SMN2CYP1A2MEN1KMT2A | |
| SCHEMBL2081039 | 0.86 | STAT3 (0.46) | KDM4ESMN1; SMN2CYP1A2MEN1KMT2A | |
| SCHEMBL4747695 | 0.81 | KCNH2 (0.48) | TOP2ATOP2BKDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL10330769 | 0.80 | TOP2A (0.53) | TOP2ATOP2BKDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL7997875 | 0.80 | GSK3B (0.45) | TOP2ATOP2BKDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL8007897 | 0.80 | GSK3B (0.45) | TOP2ATOP2BKDM4ESMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902226-B2 | Dehalogeno-compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2011-03-08 | — | — | US | disclosed |
| EP-1336611-B1 | DEHALOGENO COMPOUNDS | DAIICHI SEIYAKU CO (JP) | 2007-09-05 | — | — | EP | disclosed |
| US-20070123560-A1 | Dehalogeno-compounds | DAIICHI PHARMACEUTICAL CO., LTD. | 2007-05-31 | — | — | US | disclosed |
| US-20040063754-A1 | Dehalogeno compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2004-04-01 | — | — | US | disclosed |
| EP-1336611-A1 | DEHALOGENO COMPOUNDS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-08-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063754-A1 | Dehalogeno compounds | DEK, PGLS, RPS27L | TOP2A 376/4885TOP2B 1092/4885KDM4E 2484/4885 |
| US-20070123560-A1 | Dehalogeno-compounds | DEK, RPS27L, POLL | TOP2A 228/4885TOP2B 555/4885KDM4E 2618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.