Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18041397 | 0.95 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAHTTTHRATHRB | |
| SCHEMBL3508948 | 0.84 | SMN1; SMN2 (0.62) | SMN1; SMN2LMNAHTTTSHRASAH1 | |
| SCHEMBL17162119 | 0.83 | SMN1; SMN2 (0.60) | SMN1; SMN2LMNAHTTTSHRASAH1 | |
| SCHEMBL20819428 | 0.80 | RAB9A (0.50) | SMN1; SMN2LMNACYP2D6CYP2C9TSHR | |
| SCHEMBL20819318 | 0.79 | CYP1A2 (0.53) | LMNATHRATHRBCYP1A2CYP2D6 | |
| SCHEMBL20819283 | 0.79 | CYP1A2 (0.47) | LMNATHRATHRBCYP1A2CYP2D6 | |
| SCHEMBL7024990 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAHTTCYP1A2CYP2D6 | |
| SCHEMBL4769824 | 0.78 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNAHTTCYP1A2CYP2D6 | |
| SCHEMBL7024816 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAHTTCYP1A2CYP2D6 | |
| SCHEMBL18059296 | 0.78 | IDO1 (0.47) | SMN1; SMN2LMNAHTTADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019053617-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-03-21 | — | — | WO | disclosed |