Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | SELP | P16109 | 3/20 | 0.32 |
| ▸ | SELL | P14151 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.30 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20819536 | 0.83 | CYP3A4 (0.36) | HSD17B10NPSR1SELPSELLALDH1A1 | |
| SCHEMBL20819606 | 0.79 | LCK (0.35) | HSD17B10NPSR1SELPSELLALDH1A1 | |
| SCHEMBL20789904 | 0.78 | SELP (0.37) | SELPSELLPDE4DPDE4APDE4B | |
| SCHEMBL20819549 | 0.77 | HPGD (0.40) | HSD17B10NPSR1ALDH1A1GPR35KDM4E | |
| SCHEMBL20819588 | 0.75 | ALDH1A1 (0.45) | HSD17B10NPSR1ALDH1A1PDE4DMEN1 | |
| SCHEMBL20819559 | 0.74 | SELP (0.34) | HSD17B10NPSR1SELPSELLPDE4D | |
| SCHEMBL20790295 | 0.74 | LMNA (0.40) | SELPSELLALDH1A1KDM4EHPGD | |
| SCHEMBL20819553 | 0.74 | ALDH1A1 (0.41) | ALDH1A1PDE4DMEN1KMT2AL3MBTL1 | |
| SCHEMBL20790106 | 0.73 | PDE4A (0.40) | HSD17B10NPSR1SELPSELLPDE4D | |
| SCHEMBL31045607 | 0.73 | MAP3K14 (0.41) | ALDH1A1KDM4EHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3681864-A1 | MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE | AbbVie Overseas S.à r.l. (LU) | 2020-07-22 | — | — | EP | disclosed |
| WO-2019053634-A1 | MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE | AbbVie S.à.r.l. (LU) | 2019-03-21 | — | — | WO | disclosed |