Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SELL | P14151 | 1/20 | 0.39 |
| ▸ | SELP | P16109 | 1/20 | 0.39 |
| ▸ | SELE | P16581 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | TPMT | P51580 | 1/20 | 0.35 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.35 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.35 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | APP | P05067 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20819590 | 0.85 | ALDH1A1 (0.41) | ACHETPMTKDM4EKMT2A | |
| SCHEMBL4711506 | 0.76 | CSNK2A1 (0.43) | CSNK2A1AKR1C1AKR1B10AKR1C4AKR1C3 | |
| SCHEMBL20819588 | 0.76 | ALDH1A1 (0.45) | ACHEKMT2A | |
| SCHEMBL28681478 | 0.75 | AKR1C1 (0.45) | HDAC4TPMTAKR1C1AKR1B10AKR1C4 | |
| SCHEMBL17321011 | 0.73 | HCAR1 (0.46) | HDAC4TPMTHCAR1AKR1C1AKR1B10 | |
| SCHEMBL20819570 | 0.72 | KMT2A (0.38) | CYP3A4KMT2A | |
| SCHEMBL20819553 | 0.72 | ALDH1A1 (0.41) | ACHEKMT2A | |
| SCHEMBL20819544 | 0.71 | CYP26A1 (0.38) | ACHEAKR1C1AKR1B10AKR1C4AKR1C3 | |
| SCHEMBL1561226 | 0.69 | HDAC4 (0.59) | HDAC4AKR1C1AKR1B10AKR1C4AKR1C3 | |
| SCHEMBL27463878 | 0.68 | HCAR2 (0.47) | HDAC4AKR1C1AKR1B10AKR1C4AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3681864-A1 | MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE | AbbVie Overseas S.à r.l. (LU) | 2020-07-22 | — | — | EP | disclosed |
| WO-2019053634-A1 | MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE | AbbVie S.à.r.l. (LU) | 2019-03-21 | — | — | WO | disclosed |