Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | TYMP | P19971 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22728505 | 0.88 | HSD17B10 (0.38) | HPGDTYMPSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL18292984 | 0.82 | HPGD (0.39) | HPGDTYMPALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL13847837 | 0.66 | TYMP (0.49) | HPGDTYMPALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL15893924 | 0.62 | SMN1; SMN2 (0.45) | HPGDSMN1; SMN2ALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL23895391 | 0.61 | ALDH1A1 (0.46) | HPGDTYMPSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL13022048 | 0.60 | GAA (0.39) | HPGDSMN1; SMN2ALDH1A1HSD17B10GAA | |
| SCHEMBL25226945 | 0.60 | HRH3 (0.48) | HPGDSMN1; SMN2ALDH1A1LMNANPSR1 | |
| SCHEMBL23927478 | 0.59 | ALDH1A1 (0.48) | HPGDSMN1; SMN2ALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL25228984 | 0.58 | HRH3 (0.46) | HPGDSMN1; SMN2ALDH1A1LMNAGAA | |
| SCHEMBL17080613 | 0.57 | HRH3 (0.52) | SMN1; SMN2ALDH1A1HSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3456726-B1 | FOSAPREPITANT PHOSPHATE INTERMEDIATE AND PREPARATION METHOD THEREFOR | ZHEJIANG HUAHAI PHARM CO LTD (CN) | 2020-12-02 | — | — | EP | disclosed |
| EP-3456726-A1 | FOSAPREPITANT PHOSPHATE INTERMEDIATE AND PREPARATION METHOD THEREFOR | Zhejiang Huahai Pharmaceutical Co., Ltd (CN) | 2019-03-20 | — | — | EP | disclosed |