Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20828261 | 0.84 | L3MBTL1 (0.51) | DAOL3MBTL1ALDH1A1SIRT1KMT2A | |
| SCHEMBL20828264 | 0.79 | ALDH1A1 (0.59) | DAOKDM4EALDH1A1NR3C1SIRT1 | |
| SCHEMBL11458528 | 0.75 | DAO (0.47) | DAOKDM4EKMT2A | |
| SCHEMBL5907147 | 0.75 | L3MBTL1 (0.47) | DAOKDM4EL3MBTL1ALDH1A1MMP2 | |
| SCHEMBL30000562 | 0.69 | TAAR1 (0.60) | DAOALDH1A1TAAR1 | |
| SCHEMBL1263547 | 0.69 | TAAR1 (0.60) | DAOALDH1A1TAAR1 | |
| SCHEMBL29459538 | 0.69 | TAAR1 (0.60) | DAOALDH1A1TAAR1 | |
| SCHEMBL11733305 | 0.68 | L3MBTL1 (0.63) | KDM4EL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL13932156 | 0.67 | HTT (0.56) | DAOKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL21331828 | 0.67 | ALDH1A1 (0.49) | KDM4EL3MBTL1ALDH1A1SIRT1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200270216-A1 | COMPOSITIONS AND METHODS FOR INHIBITING N-SMASE2 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-08-27 | — | — | US | disclosed |
| WO-2019055832-A1 | COMPOSITIONS AND METHODS FOR INHIBITING N-SMASE2 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200270216-A1 | COMPOSITIONS AND METHODS FOR INHIBITING N-SMASE2 | SMN1; SMN2, PSEN2, SMPD2 | DAO 1960/4885KDM4E 3643/4885L3MBTL1 2749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.