Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.70 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11448238 | 0.82 | ALDH1A1 (0.61) | ALDH1A1NPSR1ERAP1KDM4ELMNA | |
| SCHEMBL3810225 | 0.82 | ALDH1A1 (0.61) | ALDH1A1NPSR1ERAP1KDM4EGAA | |
| SCHEMBL1888814 | 0.81 | ALDH1A1 (0.60) | ALDH1A1NPSR1ERAP1KDM4ELMNA | |
| SCHEMBL2257545 | 0.78 | MEN1 (0.44) | ALDH1A1NPSR1LMNAHSD17B10MAPT | |
| SCHEMBL20828264 | 0.73 | ALDH1A1 (0.59) | ALDH1A1NPSR1ERAP1KDM4ELMNA | |
| SCHEMBL11449106 | 0.68 | ALDH1A1 (0.65) | ALDH1A1NPSR1KDM4ELMNANPC1 | |
| SCHEMBL1268469 | 0.68 | MEN1 (0.43) | ALDH1A1NPSR1GAALMNAMAPT | |
| SCHEMBL8120565 | 0.67 | PTGS1 (0.50) | ALDH1A1LMNAMAPTMEN1POLB | |
| SCHEMBL4978570 | 0.65 | KDM4E (0.68) | ALDH1A1NPSR1KDM4ELMNANPC1 | |
| SCHEMBL20828256 | 0.65 | TYMP (0.65) | ALDH1A1KDM4ELMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200270216-A1 | COMPOSITIONS AND METHODS FOR INHIBITING N-SMASE2 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-08-27 | — | — | US | disclosed |
| WO-2019055832-A1 | COMPOSITIONS AND METHODS FOR INHIBITING N-SMASE2 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200270216-A1 | COMPOSITIONS AND METHODS FOR INHIBITING N-SMASE2 | SMN1; SMN2, PSEN2, SMPD2 | ALDH1A1 3977/4885NPSR1 4218/4885ERAP1 1362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.