Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19914376 | 0.77 | GLS (0.60) | POLBSMN1; SMN2ESR2KDM4ECYP1A2 | |
| SCHEMBL20828328 | 0.77 | POLB (0.56) | POLBSMN1; SMN2ESR2KDM4ECYP1A2 | |
| SCHEMBL21501841 | 0.76 | POLB (0.54) | POLBSMN1; SMN2ESR2KDM4ECYP1A2 | |
| SCHEMBL20828361 | 0.74 | POLB (0.52) | POLBSMN1; SMN2ESR2KDM4ECYP1A2 | |
| SCHEMBL2872397 | 0.74 | POLB (0.58) | POLBSMN1; SMN2ESR2KDM4ECYP1A2 | |
| SCHEMBL2872394 | 0.74 | POLB (0.58) | POLBSMN1; SMN2ESR2KDM4ECYP1A2 | |
| SCHEMBL1758875 | 0.74 | PKM (0.46) | SMN1; SMN2KDM4ELMNANPSR1MAPT | |
| SCHEMBL21325740 | 0.73 | POLB (0.74) | POLBSMN1; SMN2ESR2KDM4ECYP1A2 | |
| SCHEMBL1970389 | 0.73 | POLB (0.56) | POLBSMN1; SMN2ESR2KDM4ECYP1A2 | |
| SCHEMBL12649504 | 0.73 | POLB (0.60) | POLBSMN1; SMN2ESR2KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3456719-A1 | COMPOUNDS AND THEIR METHODS OF USE | Agios Pharmaceuticals, Inc. (US) | 2019-03-20 | — | — | EP | disclosed |