Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 2/20 | 0.65 |
| ▸ | CTSL | P07711 | 2/20 | 0.52 |
| ▸ | CTSS | P25774 | 2/20 | 0.52 |
| ▸ | CTSK | P43235 | 2/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22882661 | 0.89 | TACR1 (0.57) | TACR1CTSLCTSSCTSKMAPT | |
| SCHEMBL21666672 | 0.89 | TACR1 (0.60) | TACR1CTSLCTSSCTSKMAPT | |
| SCHEMBL21644791 | 0.88 | TACR1 (0.56) | TACR1CTSLCTSSCTSKMAPT | |
| SCHEMBL31725831 | 0.88 | TACR1 (0.56) | TACR1CTSLCTSSCTSKMAPT | |
| SCHEMBL30121703 | 0.88 | TACR1 (0.56) | TACR1CTSLCTSSCTSKMAPT | |
| SCHEMBL21644792 | 0.88 | TACR1 (0.56) | TACR1CTSLCTSSCTSKMAPT | |
| SCHEMBL21644784 | 0.88 | MAPT (0.59) | TACR1CTSLCTSSCTSKMAPT | |
| SCHEMBL21644783 | 0.88 | MAPT (0.59) | TACR1CTSLCTSSCTSKMAPT | |
| SCHEMBL23649364 | 0.87 | TACR1 (0.57) | TACR1CTSLCTSSCTSKMAPT | |
| SCHEMBL23649362 | 0.87 | TACR1 (0.57) | TACR1CTSLCTSSCTSKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11224609-B2 | Mithramycin derivatives having increased selectivity and anti-cancer activity | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2022-01-18 | — | — | US | disclosed |
| US-20190083519-A1 | MITHRAMYCIN DERIVATIVES HAVING INCREASED SELECTIVITY AND ANTI-CANCER ACTIVITY | UNITED STATES GOVERNMENT | 2019-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11224609-B2 | Mithramycin derivatives having increased selectivity and anti-cancer activity | TFAM, ELF3, TEAD4 | TACR1 3388/4885CTSL 2790/4885CTSS 2902/4885 |
| US-20190083519-A1 | MITHRAMYCIN DERIVATIVES HAVING INCREASED SELECTIVITY AND ANTI-CANCER ACTIVITY | TFAM, ELF3, TEAD4 | TACR1 3388/4885CTSL 2790/4885CTSS 2902/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.