Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 5/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 5/20 | 0.34 |
| ▸ | ITGAL | P20701 | 5/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL209347 | 0.90 | PTPN1 (0.36) | MEN1KMT2APTPN1PDE3BPDE3A | |
| SCHEMBL208294 | 0.85 | EPHX1 (0.36) | MEN1KMT2ACYP1A2ALDH1A1NPC1 | |
| SCHEMBL5789580 | 0.76 | PTPN1 (0.41) | ITGB2ICAM1ITGALPTPN1RXFP1 | |
| SCHEMBL209365 | 0.75 | PDE4A (0.38) | — | |
| SCHEMBL2988655 | 0.74 | PDE4D (0.38) | ALDH1A1PDE3A | |
| SCHEMBL2999256 | 0.73 | PDE4D (0.41) | NPC1PDE3A | |
| SCHEMBL2993023 | 0.73 | PDE4D (0.37) | ALDH1A1PDE3A | |
| SCHEMBL209392 | 0.71 | ALDH1A1 (0.34) | MEN1KMT2ACYP1A2ALDH1A1NPC1 | |
| SCHEMBL4696636 | 0.71 | RCE1 (0.34) | ALDH1A1 | |
| SCHEMBL208946 | 0.71 | P2RX7 (0.38) | MEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088776-B2 | Biphenyl amide lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 | ELI LILLY AND COMPANY (US) | 2012-01-03 | — | — | US | disclosed |