SCHEMBL20833722

SCHEMBL20833722

O[C@@H](CBr)c1cccc(F)c1

nearest known ligand 0.57

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CES2 O00748 1/20 0.49
CES1 P23141 1/20 0.49
HDAC4 P56524 1/20 0.46
HDAC7 Q8WUI4 1/20 0.46
HDAC5 Q9UQL6 1/20 0.46
GRIN2B Q13224 1/20 0.43
SLC6A2 P23975 2/20 0.42
SLC6A4 P31645 2/20 0.42
IDO1 P14902 1/20 0.42
TDO2 P48775 1/20 0.42
CNR2 P34972 1/20 0.41
PNMT P11086 1/20 0.41
AOC3 Q16853 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30672089 1.00 CES2 (0.49) CES2CES1HDAC4HDAC7HDAC5
SCHEMBL7783860 1.00 CES2 (0.49) CES2CES1HDAC4HDAC7HDAC5
SCHEMBL16412814 0.83 CES2 (0.49) CES2CES1HDAC4HDAC7HDAC5
SCHEMBL28998216 0.83 CES2 (0.49) CES2CES1HDAC4HDAC7HDAC5
SCHEMBL30988818 0.83 CES2 (0.49) CES2CES1HDAC4HDAC7HDAC5
SCHEMBL23489619 0.83 CES2 (0.49) CES2CES1HDAC4HDAC7HDAC5
SCHEMBL17660052 0.83 CES2 (0.49) CES2CES1HDAC4HDAC7HDAC5
SCHEMBL16419139 0.83 CES2 (0.49) CES2CES1HDAC4HDAC7HDAC5
SCHEMBL16559381 0.82 SLC6A2 (0.46) CES2CES1HDAC4HDAC7HDAC5
SCHEMBL21680243 0.82 PNMT (0.61) CES2CES1SLC6A2SLC6A4PNMT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12280023-B2 Fluorophenyl beta-hydroxyethylamines and their use in the treatment of hyperglycaemia ATROGI AB (SE) 2025-04-22 US disclosed
CN-118930444-A Fluorophenyl beta-hydroxyethylamine and its use in the treatment of hyperglycaemia 阿托基公司 2024-11-12 CN disclosed
CN-111148731-B Fluorophenyl beta-hydroxyethylamine and its use in the treatment of hyperglycaemia 阿托基公司 2024-07-09 CN disclosed
US-20230364035-A1 FLUOROPHENYL BETA-HYDROXYETHYLAMINES AND THEIR USE IN THE TREATMENT OF HYPERGLYCAEMIA ATROGI AB (SE) 2023-11-16 US disclosed
US-20230364035-A1 FLUOROPHENYL BETA-HYDROXYETHYLAMINES AND THEIR USE IN THE TREATMENT OF HYPERGLYCAEMIA ATROGI AB (SE) 2023-11-16 US disclosed
US-20230364035-A1 FLUOROPHENYL BETA-HYDROXYETHYLAMINES AND THEIR USE IN THE TREATMENT OF HYPERGLYCAEMIA ATROGI AB (SE) 2023-11-16 US disclosed
EP-3681857-B1 FLUOROPHENYL BETA-HYDROXYETHYLAMINES AND THEIR USE IN THE TREATMENT OF HYPERGLYCAEMIA ATROGI AB (SE) 2023-11-08 EP disclosed
EP-3681857-B1 FLUOROPHENYL BETA-HYDROXYETHYLAMINES AND THEIR USE IN THE TREATMENT OF HYPERGLYCAEMIA ATROGI AB (SE) 2023-11-08 EP disclosed
EP-4249054-A2 FLUOROPHENYL BETA-HYDROXYETHYLAMINES AND THEIR USE IN THE TREATMENT OF HYPERGLYCAEMIA Atrogi AB (SE) 2023-09-27 EP disclosed
EP-4249054-A2 FLUOROPHENYL BETA-HYDROXYETHYLAMINES AND THEIR USE IN THE TREATMENT OF HYPERGLYCAEMIA Atrogi AB (SE) 2023-09-27 EP disclosed
US-11648216-B2 Fluorophenyl beta-hydroxyethylamines and their use in the treatment of hyperglycaemia ATROGI AB (SE) 2023-05-16 US disclosed
US-11648216-B2 Fluorophenyl beta-hydroxyethylamines and their use in the treatment of hyperglycaemia ATROGI AB (SE) 2023-05-16 US disclosed
US-11648216-B2 Fluorophenyl beta-hydroxyethylamines and their use in the treatment of hyperglycaemia ATROGI AB (SE) 2023-05-16 US disclosed
US-20200268688-A1 FLUOROPHENYL BETA-HYDROXYETHYLAMINES AND THEIR USE IN THE TREATMENT OF HYPERGLYCAEMIA ATROGI AB (SE) 2020-08-27 US disclosed
US-20200268688-A1 FLUOROPHENYL BETA-HYDROXYETHYLAMINES AND THEIR USE IN THE TREATMENT OF HYPERGLYCAEMIA ATROGI AB (SE) 2020-08-27 US disclosed
CN-111148731-A Fluorophenyl β -hydroxyethylamine and use thereof in the treatment of hyperglycaemia 阿托基公司 2020-05-12 CN disclosed
WO-2019053426-A1 FLUOROPHENYL BETA-HYDROXYETHYLAMINES AND THEIR USE IN THE TREATMENT OF HYPERGLYCAEMIA ATROGI AB (SE) 2019-03-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200268688-A1 FLUOROPHENYL BETA-HYDROXYETHYLAMINES AND THEIR USE IN THE TREATMENT OF HYPERGLYCAEMIA GPR119, SLC5A2, SLC5A1 CES2 190/4885CES1 323/4885HDAC4 1136/4885
US-12280023-B2 Fluorophenyl beta-hydroxyethylamines and their use in the treatment of hyperglycaemia GPR119, SLC5A2, SLC5A1 CES2 190/4885CES1 323/4885HDAC4 1136/4885
US-20230364035-A1 FLUOROPHENYL BETA-HYDROXYETHYLAMINES AND THEIR USE IN THE TREATMENT OF HYPERGLYCAEMIA GPR119, SLC5A2, SLC5A1 CES2 190/4885CES1 323/4885HDAC4 1136/4885
US-11648216-B2 Fluorophenyl beta-hydroxyethylamines and their use in the treatment of hyperglycaemia GPR119, SLC5A2, SLC5A1 CES2 190/4885CES1 323/4885HDAC4 1136/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.