SCHEMBL20834754

SCHEMBL20834754

FC(F)(F)c1cccc(-c2ccc(-n3c4ccccc4c4ccc(-c5ccc(C(F)(F)F)cc5C(F)(F)F)cc43)cc2-c2nc(-c3ccccc3)nc(-c3ccccc3)n2)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 4/20 0.37
CYP2C9 P11712 1/20 0.36
SCN9A Q15858 1/20 0.36
ATM Q13315 2/20 0.36
EDNRB P24530 1/20 0.36
EDNRA P25101 1/20 0.36
PPARG P37231 1/20 0.36
PPARA Q07869 1/20 0.36
MEN1 O00255 1/20 0.36
NPC1 O15118 1/20 0.36
KMT2A Q03164 1/20 0.36
HSD17B1 P14061 1/20 0.35
HSD17B2 P37059 1/20 0.35
ALDH1A1 P00352 1/20 0.35
LMNA P02545 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
KIF11 P52732 1/20 0.35
NR3C1 P04150 2/20 0.35
ADORA2A P29274 1/20 0.35
ADORA1 P30542 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20834759 0.97 CYP2C9 (0.38) ABCG2CYP2C9SCN9AATMEDNRB
SCHEMBL20777473 0.95 KIF11 (0.34) ABCG2CYP2C9SCN9AATMEDNRB
SCHEMBL20834742 0.95 S1PR1 (0.39) ABCG2CYP2C9SCN9AEDNRBEDNRA
SCHEMBL20834751 0.94 ABCG2 (0.37) ABCG2CYP2C9SCN9AATMEDNRB
SCHEMBL20905076 0.94 NT5E (0.38) ABCG2CYP2C9SCN9AEDNRBEDNRA
SCHEMBL23679083 0.93 KIF11 (0.36) ABCG2CYP2C9SCN9AEDNRBEDNRA
SCHEMBL20904843 0.93 NR3C1 (0.39) ABCG2NPSR1NR3C1ALOX5APFEN1
SCHEMBL20777485 0.92 S1PR1 (0.36) ABCG2CYP2C9SCN9AEDNRBEDNRA
SCHEMBL23543345 0.92 ABCG2 (0.40) ABCG2ATMPPARGPPARAMEN1
SCHEMBL20834739 0.92 S1PR1 (0.41) ABCG2CYP2C9SCN9AEDNRBEDNRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3684884-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2021-06-23 EP disclosed
WO-2019053049-A1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-03-21 WO disclosed