Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20838978 | 1.00 | HRH2 (0.35) | HRH2HRH1KITSCN9A | |
| SCHEMBL21063430 | 0.87 | — | — | |
| SCHEMBL28506466 | 0.79 | SMN1; SMN2 (0.47) | — | |
| SCHEMBL14306821 | 0.76 | SMN1; SMN2 (0.45) | HRH2HRH1 | |
| SCHEMBL21063385 | 0.75 | SMN1; SMN2 (0.33) | — | |
| SCHEMBL28956751 | 0.74 | PIK3CD (0.35) | — | |
| SCHEMBL7344719 | 0.74 | GAA (0.42) | — | |
| SCHEMBL14660329 | 0.74 | BIRC2 (0.51) | — | |
| SCHEMBL28507614 | 0.74 | ALDH1A1 (0.46) | — | |
| SCHEMBL13110280 | 0.73 | HSD11B1 (0.40) | HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3684775-A1 | SUBSTITUTED DIHYDROTHIENOPYRIMIDINES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2020-07-29 | — | — | EP | disclosed |
| WO-2019057806-A1 | SUBSTITUTED DIHYDROTHIENOPYRIMIDINES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2019-03-28 | — | — | WO | disclosed |