Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | LOX | P28300 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5470613 | 0.87 | GAA (0.48) | GAAMAPTKDM4ERAB9AKMT2A | |
| SCHEMBL31254773 | 0.86 | MAPT (0.55) | GAAMAPTKDM4ENPC1RAB9A | |
| SCHEMBL19644103 | 0.85 | GAA (0.58) | GAAALOX5ATMSMN1; SMN2ALOX15 | |
| SCHEMBL29389131 | 0.85 | GAA (0.58) | GAAALOX5ATMSMN1; SMN2ALOX15 | |
| SCHEMBL5463910 | 0.82 | KMT2A (0.66) | GAAMAPTKDM4ENPC1RAB9A | |
| SCHEMBL22219724 | 0.77 | SMN1; SMN2 (0.45) | ALOX5ATMSMN1; SMN2ALOX15KDM4E | |
| SCHEMBL178802 | 0.77 | KMT2A (0.51) | GAAALOX5MAPTKDM4EKMT2A | |
| SCHEMBL761303 | 0.74 | KMT2A (0.62) | GAASMN1; SMN2MAPTKDM4EKMT2A | |
| SCHEMBL9454642 | 0.73 | ATM (0.64) | GAAALOX5ATMSMN1; SMN2ALOX15 | |
| SCHEMBL765763 | 0.73 | LOX (0.49) | GAASMN1; SMN2MAPTKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3684354-B1 | XPA INHIBITOR COMPOUNDS AND THEIR USE | UNIV INDIANA RES & TECH CORP (US) | 2023-11-15 | — | — | EP | disclosed |
| EP-3684354-B1 | XPA INHIBITOR COMPOUNDS AND THEIR USE | UNIV INDIANA RES & TECH CORP (US) | 2023-11-15 | — | — | EP | disclosed |
| US-11207296-B2 | XPA inhibitor compounds and their use | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2021-12-28 | — | — | US | disclosed |
| US-11207296-B2 | XPA inhibitor compounds and their use | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2021-12-28 | — | — | US | disclosed |
| EP-3684354-A1 | XPA INHIBITOR COMPOUNDS AND THEIR USE | Indiana University Research and Technology Corporation (US) | 2020-07-29 | — | — | EP | disclosed |
| US-20200222367-A1 | XPA INHIBITOR COMPOUNDS AND THEIR USE | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2020-07-16 | — | — | US | disclosed |
| US-20200222367-A1 | XPA INHIBITOR COMPOUNDS AND THEIR USE | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2020-07-16 | — | — | US | disclosed |
| WO-2019060260-A1 | XPA INHIBITOR COMPOUNDS AND THEIR USE | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2019-03-28 | — | — | WO | disclosed |
| WO-2019060260-A1 | XPA INHIBITOR COMPOUNDS AND THEIR USE | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2019-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200222367-A1 | XPA INHIBITOR COMPOUNDS AND THEIR USE | XPOT, XPA, ERCC4 | GAA 1716/4885ALOX5 4636/4885ATM 559/4885 |
| US-11207296-B2 | XPA inhibitor compounds and their use | XPOT, XPA, ERCC4 | GAA 1716/4885ALOX5 4636/4885ATM 559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.