Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 19/20 | 0.63 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.63 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2086327 | 0.91 | CXCR3 (0.74) | CCR5CXCR4CXCR3 | |
| SCHEMBL6614422 | 0.86 | CCR5 (0.81) | CCR5CXCR4CXCR3 | |
| SCHEMBL6616558 | 0.86 | CCR5 (0.81) | CCR5CXCR4CXCR3 | |
| SCHEMBL6611654 | 0.86 | CCR5 (0.81) | CCR5CXCR4CXCR3 | |
| SCHEMBL6615594 | 0.85 | CCR5 (0.79) | CCR5CXCR4CXCR3 | |
| SCHEMBL6611258 | 0.84 | CCR5 (0.72) | CCR5CXCR4CXCR3 | |
| SCHEMBL6616935 | 0.84 | CCR5 (0.72) | CCR5CXCR4CXCR3 | |
| SCHEMBL6612455 | 0.84 | CCR5 (0.75) | CCR5CXCR4CXCR3 | |
| SCHEMBL2085867 | 0.83 | CXCR3 (0.82) | CCR5CXCR3CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6612428 | 0.83 | CCR5 (0.82) | CCR5CXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110052612-A1 | SPIROPIPERIDINE COMPOUND AND MEDICINAL USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2011-03-03 | — | — | US | disclosed |
| EP-1889622-A1 | SPIROPIPERIDINE COMPOUND AND MEDICINAL USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2008-02-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110052612-A1 | SPIROPIPERIDINE COMPOUND AND MEDICINAL USE THEREOF | CXCR3, CFTR, CXCR1 | CCR5 10/4885CXCR4 61/4885CXCR3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.