Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 9/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.40 |
| ▸ | GRN | P28799 | 1/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.40 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2025620 | 0.83 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11GRN | |
| SCHEMBL2082236 | 0.83 | MAPK14 (0.42) | MAPK14MAPK13MAPK12MAPK11GRN | |
| SCHEMBL5052142 | 0.82 | MAPK14 (0.45) | MAPK14MAPK13MAPK12MAPK11GRN | |
| SCHEMBL2081248 | 0.81 | CYP1A2 (0.40) | MAPK14MAPK13MAPK12MAPK11GRN | |
| SCHEMBL2082586 | 0.80 | RAB9A (0.42) | MAPK14MAPK13MAPK12MAPK11GRN | |
| SCHEMBL5052166 | 0.79 | GRN (0.43) | MAPK14MAPK13MAPK12MAPK11GRN | |
| SCHEMBL2025289 | 0.79 | HPGD (0.43) | MAPK14MAPK13MAPK12MAPK11GRN | |
| Hydrochloric Acid SCHEMBL2025286 | 0.78 | HPGD (0.42) | MAPK14MAPK13MAPK12MAPK11GRN | |
| SCHEMBL4486598 | 0.77 | RIPK2 (0.39) | MAPK14MAPK13MAPK12MAPK11GRN | |
| SCHEMBL2083183 | 0.77 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163756-B2 | For example,1-(3-t-butyl-1- (1,2,3,4-tetrahydro- isoquinolin-6-yl)-1H- pyrazol-5-yl)-3-(3- cyanophenyl)urea; for treatment of mammalian cancers and inflammatory diseases including rheumatoid arthritis, retinopathies | DECIPHERA PHARMACEUTICALS, LLC (US) | 2012-04-24 | — | — | US | disclosed |