Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 4/20 | 0.43 |
| ▸ | MMP12 | P39900 | 4/20 | 0.43 |
| ▸ | MMP8 | P22894 | 3/20 | 0.43 |
| ▸ | MMP13 | P45452 | 3/20 | 0.43 |
| ▸ | MMP14 | P50281 | 3/20 | 0.43 |
| ▸ | MMP16 | P51512 | 3/20 | 0.43 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.43 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2202601 | 0.86 | HSD17B10 (0.46) | HSD17B10CA12CA1CA2CA7 | |
| Hydrochloric Acid SCHEMBL9509325 | 0.84 | HSD17B10 (0.45) | HSD17B10CA12CA1CA2CA7 | |
| SCHEMBL31582834 | 0.83 | MTNR1A (0.51) | CA12CA1CA2CA7CA9 | |
| SCHEMBL18254201 | 0.80 | PDE4A (0.41) | HSD17B10CA12CA1CA2CA7 | |
| SCHEMBL29431297 | 0.79 | HSD17B10 (0.61) | HSD17B10POLBSMN1; SMN2CXCL8MEN1 | |
| SCHEMBL155982 | 0.79 | HSD17B10 (0.61) | HSD17B10POLBSMN1; SMN2CXCL8MEN1 | |
| SCHEMBL991380 | 0.78 | KMT2A (0.54) | HSD17B10CA12CA1CA2CA7 | |
| SCHEMBL2310865 | 0.78 | STING1 (0.54) | HSD17B10CA12CA1CA2CA7 | |
| SCHEMBL2874758 | 0.78 | IDO1 (0.56) | HSD17B10CA12CA1CA2CA7 | |
| SCHEMBL29639215 | 0.78 | KMT2A (0.54) | HSD17B10CA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019057946-A1 | MULTI-CYCLIC AROMATIC COMPOUNDS AS FACTOR D INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2019-03-28 | — | — | WO | disclosed |