Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11132561 | 0.89 | HTT (0.51) | IDO1ALOX5PTGS2HSD17B10LMNA | |
| SCHEMBL28235226 | 0.86 | IDO1 (0.60) | IDO1ALOX5PTGS2ALDH1A1HSD17B10 | |
| Syringol SCHEMBL28068397 | 0.84 | CXCL8 (0.57) | IDO1ALOX5PTGS2ALDH1A1HSD17B10 | |
| SCHEMBL29431297 | 0.83 | HSD17B10 (0.61) | HSD17B10LMNAMAPTAKR1B1TSHR | |
| SCHEMBL155982 | 0.83 | HSD17B10 (0.61) | HSD17B10LMNAMAPTAKR1B1TSHR | |
| SCHEMBL3691207 | 0.83 | ALOX5 (0.59) | IDO1ALOX5PTGS2ALDH1A1HSD17B10 | |
| SCHEMBL28840672 | 0.83 | ALOX5 (0.55) | IDO1ALOX5PTGS2ALDH1A1HSD17B10 | |
| SCHEMBL5120093 | 0.83 | L3MBTL1 (0.53) | KDM4EMAPTAKR1B1TSHRTDP1 | |
| SCHEMBL2310865 | 0.82 | STING1 (0.54) | ALDH1A1HSD17B10LMNAKDM4EMAPT | |
| SCHEMBL991380 | 0.82 | KMT2A (0.54) | ALDH1A1HSD17B10KDM4EHPGDCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461384-B2 | Preparation of amides from an acid and amine for intermediates in the synthesis of morphinans | MALLINCKRODT LLC (US) | 2013-06-11 | — | — | US | disclosed |
| US-8445682-B2 | Preparation of 3,4-dihydroisoquinolines from an acid and an amine | MALLINCKRODT LLC (US) | 2013-05-21 | — | — | US | disclosed |
| US-8232400-B2 | Preparation of 3,4-dihydroisoquinolines in the synthesis of morphinans | MALLINCKRODT LLC (US) | 2012-07-31 | — | — | US | disclosed |
| EP-2177504-A1 | Preparation of amides from an acid and amine for intermediates in the synthesis of morphinans | Mallinckrodt Inc. (US) | 2010-04-21 | — | — | EP | disclosed |
| US-20100063290-A1 | Preparation of 3,4-Dihydroisoquinolines from an Acid and an Amine | MALLINCKRODT PHARMACEUTICALS IRELAND LIMITED (IE) | 2010-03-11 | — | — | US | disclosed |
| EP-2161253-A2 | Process for the preparation of 3,4-dihydroisoquinolines in the synthesis of morphinans | Mallinckrodt Inc. (US) | 2010-03-10 | — | — | EP | disclosed |
| US-20090247760-A1 | Preparation of Amides from an Acid and Amine for Intermediates in the Synthesis of Morphinans | MALLINCKRODT INC. (US) | 2009-10-01 | — | — | US | disclosed |
| US-20090247761-A1 | Preparation of 3,4-Dihydroisoquinolines in the Synthesis of Morphinans | MALLINCKRODT INC. (US) | 2009-10-01 | — | — | US | disclosed |
| EP-2099745-A2 | PREPARATION OF 3,4-DIHYDROISOQUINOLINES FROM AN ACID AND AN AMINE | Mallinckrodt Inc. (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008073390-A2 | PREPARATION OF 3,4-DIHYDROISOQUINOLINES FROM AN ACID AND AN AMINE | MALLINCKRODT INC. (US) | 2008-06-19 | — | — | WO | disclosed |
| US-20080051418-A1 | Arylalkanoic Acid Derivative | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-02-28 | — | — | US | disclosed |
| EP-1829863-A1 | ARYLALKANOIC ACID DERIVATIVE | Takeda Pharmaceutical Company Limited (JP) | 2007-09-05 | — | — | EP | disclosed |
| US-20060148858-A1 | 1, 2-Azole derivatives with hypoglycemic and hypolipidemic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247761-A1 | Preparation of 3,4-Dihydroisoquinolines in the Synthesis of Morphinans | PNN, CDKL3, ORAI3 | IDO1 430/4885ALOX5 611/4885PTGS2 3369/4885 |
| US-20100063290-A1 | Preparation of 3,4-Dihydroisoquinolines from an Acid and an Amine | PNN, AOX1, PAM | IDO1 487/4885ALOX5 349/4885PTGS2 3302/4885 |
| US-20060148858-A1 | 1, 2-Azole derivatives with hypoglycemic and hypolipidemic activity | GPR119, SLC5A1, CYP4B1 | IDO1 660/4885ALOX5 1513/4885PTGS2 4593/4885 |
| US-20080051418-A1 | Arylalkanoic Acid Derivative | INSR, NPY1R, GPR119 | IDO1 1352/4885ALOX5 672/4885PTGS2 4502/4885 |
| US-20090247760-A1 | Preparation of Amides from an Acid and Amine for Intermediates in the Synthesis of Morphinans | PNN, PAM, NPM1 | IDO1 334/4885ALOX5 312/4885PTGS2 3564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.