Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11977597 | 1.00 | SLC6A4 (0.41) | SLC6A4TACR1IDO1CYP2D6CYP3A4 | |
| SCHEMBL20844683 | 1.00 | SLC6A4 (0.41) | SLC6A4TACR1IDO1CYP2D6CYP3A4 | |
| SCHEMBL5712566 | 0.85 | SLC6A4 (0.48) | SLC6A4ANPEPENPEPLMNA | |
| SCHEMBL11664457 | 0.82 | TACR1 (0.41) | SLC6A4TACR1IDO1CYP2D6CYP3A4 | |
| SCHEMBL20844633 | 0.80 | TACR1 (0.40) | SLC6A4TACR1IDO1CYP2D6CYP3A4 | |
| SCHEMBL7241495 | 0.80 | TACR1 (0.40) | SLC6A4TACR1IDO1CYP2D6CYP3A4 | |
| SCHEMBL27557391 | 0.79 | SLC6A3 (0.38) | SLC6A4TACR1IDO1CYP2D6CYP3A4 | |
| SCHEMBL4172487 | 0.78 | AOC3 (0.45) | SLC6A4TACR1IDO1ANPEPENPEP | |
| SCHEMBL9439972 | 0.78 | CYP3A4 (0.44) | SLC6A4CYP2D6CYP3A4SLC6A2SLC6A3 | |
| SCHEMBL20844635 | 0.78 | SLC6A4 (0.42) | SLC6A4CYP3A4ANPEPENPEPHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021072156-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |
| WO-2019057946-A1 | MULTI-CYCLIC AROMATIC COMPOUNDS AS FACTOR D INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2019-03-28 | — | — | WO | disclosed |