SCHEMBL20844809

SCHEMBL20844809

Cc1ccc(-c2noc(C3CCC(O)CC3)n2)cc1NC(=O)c1cnc2ccccn12

nearest known ligand 0.93

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
KIT P10721 20/20 0.93

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14739173 0.97 KIT (1.00) KIT
SCHEMBL14738218 0.93 KIT (1.00) KIT
SCHEMBL14738588 0.93 KIT (1.00) KIT
SCHEMBL21387471 0.93 KIT (0.89) KIT
SCHEMBL14738606 0.93 KIT (1.00) KIT
SCHEMBL14739234 0.93 KIT (1.00) KIT
SCHEMBL14750948 0.93 KIT (1.00) KIT
SCHEMBL14739898 0.92 KIT (0.90) KIT
SCHEMBL21372452 0.91 KIT (0.86) KIT
SCHEMBL14740017 0.91 KIT (0.86) KIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2751102-B1 COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS NOVARTIS AG (CH) 2019-03-27 EP disclosed