SCHEMBL20846705

SCHEMBL20846705

CN(C(=O)c1ccc(F)cc1)c1cccc(C(=O)Nc2c(I)cc(C(F)(C(F)(F)F)C(F)(F)C(F)(F)F)cc2OC(F)F)c1F

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
RXFP1 Q9HBX9 2/20 0.34
ALDH1A1 P00352 1/20 0.33
DHODH Q02127 2/20 0.32
SCN8A Q9UQD0 2/20 0.32
SCN10A Q9Y5Y9 2/20 0.32
MEN1 O00255 2/20 0.30
KMT2A Q03164 2/20 0.30
POLB P06746 1/20 0.30
GPBAR1 Q8TDU6 1/20 0.30
KDM4E B2RXH2 1/20 0.30
TUBB4A P04350 1/20 0.30
TUBB P07437 1/20 0.30
TUBA3C P0DPH7 1/20 0.30
TUBA1B P68363 1/20 0.30
TUBA4A P68366 1/20 0.30
TUBB4B P68371 1/20 0.30
TUBB3 Q13509 1/20 0.30
TUBB2A Q13885 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22402103 0.96 HTT (0.38) HTTSMN1; SMN2RXFP1ALDH1A1DHODH
SCHEMBL31348977 0.92 HTT (0.37) HTTSMN1; SMN2RXFP1ALDH1A1SCN8A
SCHEMBL20846715 0.91 HTT (0.34) HTTSMN1; SMN2RXFP1ALDH1A1DHODH
SCHEMBL1766937 0.90 RXFP1 (0.35) RXFP1MEN1KMT2APOLBGPBAR1
SCHEMBL22402119 0.88 DHODH (0.34) HTTSMN1; SMN2RXFP1DHODHSCN8A
SCHEMBL31348989 0.87 HTT (0.38) HTTSMN1; SMN2RXFP1ALDH1A1SCN8A
SCHEMBL22402095 0.87 HTT (0.36) HTTSMN1; SMN2RXFP1ALDH1A1DHODH
SCHEMBL20846830 0.86 KCNK3 (0.36) RXFP1DHODHMEN1KMT2APOLB
SCHEMBL1766327 0.86 RXFP1 (0.35) RXFP1MEN1KMT2AGPBAR1KDM4E
SCHEMBL1766965 0.86 KDM4E (0.36) RXFP1MEN1KMT2APOLBGPBAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230226037-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2023-07-20 US disclosed
US-11696913-B2 Prolonged ectoparasite-controlling agent for animal MITSUI CHEMICALS AGRO, INC. (JP) 2023-07-11 US disclosed
US-20200281914-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MITSUI CHEMICALS AGRO, INC. (JP) 2020-09-10 US disclosed
WO-2019059412-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MITSUI CHEMICALS AGRO, INC. (JP) 2019-03-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11696913-B2 Prolonged ectoparasite-controlling agent for animal MTX1, ENPP1, CAT HTT 1020/4885SMN1; SMN2 1114/4885RXFP1 1867/4885
US-20230226037-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MTX1, ENPP1, CAT HTT 1020/4885SMN1; SMN2 1114/4885RXFP1 1867/4885
US-20200281914-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MTX1, ENPP1, CAT HTT 1020/4885SMN1; SMN2 1114/4885RXFP1 1867/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.