SCHEMBL22402103

SCHEMBL22402103

CN(C(=O)c1ccc(F)cc1)c1cccc(C(=O)Nc2c(I)cc(C(F)(C(F)(F)F)C(F)(F)F)cc2OC(F)F)c1F

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
ALDH1A1 P00352 1/20 0.34
RXFP1 Q9HBX9 2/20 0.34
DHODH Q02127 2/20 0.33
SCN8A Q9UQD0 2/20 0.33
SCN10A Q9Y5Y9 2/20 0.33
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
POLB P06746 1/20 0.32
KDM4E B2RXH2 1/20 0.32
GPBAR1 Q8TDU6 1/20 0.31
TUBB4A P04350 1/20 0.31
TUBB P07437 1/20 0.31
TUBA3C P0DPH7 1/20 0.31
TUBA1B P68363 1/20 0.31
TUBA4A P68366 1/20 0.31
TUBB4B P68371 1/20 0.31
TUBB3 Q13509 1/20 0.31
TUBB2A Q13885 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20846705 0.96 HTT (0.36) HTTSMN1; SMN2ALDH1A1RXFP1DHODH
SCHEMBL22402119 0.92 DHODH (0.34) HTTSMN1; SMN2RXFP1DHODHSCN8A
SCHEMBL31348989 0.91 HTT (0.38) HTTSMN1; SMN2ALDH1A1RXFP1SCN8A
SCHEMBL22402095 0.90 HTT (0.36) HTTSMN1; SMN2ALDH1A1RXFP1DHODH
SCHEMBL20846830 0.90 KCNK3 (0.36) RXFP1DHODHMEN1KMT2APOLB
SCHEMBL1766965 0.90 KDM4E (0.36) RXFP1MEN1KMT2APOLBKDM4E
SCHEMBL20846710 0.89 GPBAR1 (0.33) RXFP1SCN8ASCN10AGPBAR1
SCHEMBL31348977 0.87 HTT (0.37) HTTSMN1; SMN2ALDH1A1RXFP1SCN8A
SCHEMBL20846715 0.87 HTT (0.34) HTTSMN1; SMN2ALDH1A1RXFP1DHODH
SCHEMBL1766510 0.86 RXFP1 (0.35) RXFP1MEN1KMT2AKDM4EGPBAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230226037-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2023-07-20 US disclosed
US-11696913-B2 Prolonged ectoparasite-controlling agent for animal MITSUI CHEMICALS AGRO, INC. (JP) 2023-07-11 US disclosed
US-20200281914-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MITSUI CHEMICALS AGRO, INC. (JP) 2020-09-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11696913-B2 Prolonged ectoparasite-controlling agent for animal MTX1, ENPP1, CAT HTT 1020/4885SMN1; SMN2 1114/4885ALDH1A1 390/4885
US-20230226037-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MTX1, ENPP1, CAT HTT 1020/4885SMN1; SMN2 1114/4885ALDH1A1 390/4885
US-20200281914-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MTX1, ENPP1, CAT HTT 1020/4885SMN1; SMN2 1114/4885ALDH1A1 390/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.