SCHEMBL20846830

SCHEMBL20846830

CN(C(=O)c1ccc(F)cc1)c1cccc(C(=O)Nc2c(I)cc(C(F)(C(F)(F)F)C(F)(F)F)cc2OC(F)(F)F)c1F

nearest known ligand 0.36

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
KCNK3 O14649 4/20 0.36
KCNK9 Q9NPC2 4/20 0.36
RXFP1 Q9HBX9 2/20 0.35
BRAF P15056 1/20 0.35
GPBAR1 Q8TDU6 3/20 0.35
F2R P25116 1/20 0.34
MEN1 O00255 3/20 0.32
KMT2A Q03164 3/20 0.32
POLB P06746 1/20 0.32
KDM4E B2RXH2 1/20 0.32
DHODH Q02127 1/20 0.32
ROCK2 O75116 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20846708 0.92 KCNK3 (0.33) KCNK3KCNK9RXFP1BRAFGPBAR1
SCHEMBL1766965 0.91 KDM4E (0.36) RXFP1GPBAR1MEN1KMT2APOLB
SCHEMBL22402103 0.90 HTT (0.38) RXFP1GPBAR1MEN1KMT2APOLB
SCHEMBL20846797 0.90 KCNK3 (0.36) KCNK3KCNK9RXFP1BRAFGPBAR1
SCHEMBL20841417 0.88 GPBAR1 (0.36) RXFP1BRAFGPBAR1
SCHEMBL29427441 0.87 RXFP1 (0.35) RXFP1GPBAR1MEN1KMT2AKDM4E
SCHEMBL1766510 0.87 RXFP1 (0.35) RXFP1GPBAR1MEN1KMT2AKDM4E
SCHEMBL1766937 0.87 RXFP1 (0.35) RXFP1GPBAR1MEN1KMT2APOLB
SCHEMBL20846705 0.86 HTT (0.36) RXFP1GPBAR1MEN1KMT2APOLB
SCHEMBL20846713 0.86 KCNK3 (0.35) KCNK3KCNK9RXFP1BRAFGPBAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230226037-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2023-07-20 US disclosed
US-11696913-B2 Prolonged ectoparasite-controlling agent for animal MITSUI CHEMICALS AGRO, INC. (JP) 2023-07-11 US disclosed
US-20200281914-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MITSUI CHEMICALS AGRO, INC. (JP) 2020-09-10 US disclosed
WO-2019059412-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MITSUI CHEMICALS AGRO, INC. (JP) 2019-03-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11696913-B2 Prolonged ectoparasite-controlling agent for animal MTX1, ENPP1, CAT KCNK3 2461/4885KCNK9 2598/4885RXFP1 1867/4885
US-20230226037-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MTX1, ENPP1, CAT KCNK3 2461/4885KCNK9 2598/4885RXFP1 1867/4885
US-20200281914-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MTX1, ENPP1, CAT KCNK3 2461/4885KCNK9 2598/4885RXFP1 1867/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.