SCHEMBL20846802

SCHEMBL20846802

Cc1ccc(C(=O)N(C)c2cccc(C(=O)Nc3c(I)cc(C(F)(C(F)(F)F)C(F)(F)F)cc3C(F)(F)F)c2F)cc1

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 3/20 0.38
MEN1 O00255 1/20 0.34
NPC1 O15118 1/20 0.34
MAPT P10636 1/20 0.34
HTT P42858 1/20 0.34
RAB9A P51151 1/20 0.34
KMT2A Q03164 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
KCNK3 O14649 1/20 0.34
KCNK9 Q9NPC2 1/20 0.34
GPBAR1 Q8TDU6 3/20 0.34
CTSS P25774 1/20 0.33
PTGES O14684 2/20 0.33
HDAC8 Q9BY41 1/20 0.33
KCNJ11 Q14654 1/20 0.32
POLB P06746 1/20 0.32
RECQL P46063 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1766510 0.94 RXFP1 (0.35) RXFP1MEN1MAPTKMT2AGPBAR1
SCHEMBL29427441 0.94 RXFP1 (0.35) RXFP1MEN1MAPTKMT2AGPBAR1
SCHEMBL20846798 0.94 RXFP1 (0.37) RXFP1MEN1NPC1MAPTRAB9A
SCHEMBL29427437 0.93 KCNK3 (0.38) RXFP1KCNK3KCNK9GPBAR1CTSS
SCHEMBL1766623 0.93 KCNK3 (0.38) RXFP1KCNK3KCNK9GPBAR1CTSS
SCHEMBL20846841 0.92 RORC (0.35) RXFP1KCNK3KCNK9GPBAR1CTSS
SCHEMBL20846803 0.92 RXFP1 (0.38) RXFP1RAB9AGPBAR1PTGES
SCHEMBL25805064 0.92 PTGES (0.32) RXFP1KCNK3KCNK9GPBAR1CTSS
SCHEMBL20846769 0.91 NR1H4 (0.33) RXFP1KMT2AGPBAR1CTSSPTGES
SCHEMBL20846845 0.91 HDAC8 (0.35) RXFP1CTSSPTGESHDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230226037-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2023-07-20 US disclosed
US-20230226037-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2023-07-20 US disclosed
US-11696913-B2 Prolonged ectoparasite-controlling agent for animal MITSUI CHEMICALS AGRO, INC. (JP) 2023-07-11 US disclosed
US-11696913-B2 Prolonged ectoparasite-controlling agent for animal MITSUI CHEMICALS AGRO, INC. (JP) 2023-07-11 US disclosed
US-20200281914-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MITSUI CHEMICALS AGRO, INC. (JP) 2020-09-10 US disclosed
WO-2019059412-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MITSUI CHEMICALS AGRO, INC. (JP) 2019-03-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11696913-B2 Prolonged ectoparasite-controlling agent for animal MTX1, ENPP1, CAT RXFP1 1867/4885MEN1 686/4885NPC1 2692/4885
US-20230226037-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MTX1, ENPP1, CAT RXFP1 1867/4885MEN1 686/4885NPC1 2692/4885
US-20200281914-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MTX1, ENPP1, CAT RXFP1 1867/4885MEN1 686/4885NPC1 2692/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.