Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
| ▸ | MMP7 | P09237 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19369325 | 0.80 | TP53 (0.35) | TP53ALDH1A1LMNAPIK3C3MEN1 | |
| SCHEMBL20846885 | 0.79 | TP53 (0.34) | TP53ALDH1A1LMNA | |
| SCHEMBL19369124 | 0.78 | DRD2 (0.40) | — | |
| SCHEMBL22200199 | 0.77 | TP53 (0.33) | TP53 | |
| SCHEMBL24377568 | 0.77 | TP53 (0.33) | TP53 | |
| SCHEMBL16264635 | 0.73 | MEN1 (0.40) | TP53ALDH1A1MEN1KMT2AMMP1 | |
| SCHEMBL356809 | 0.72 | TP53 (0.45) | TP53ALDH1A1LMNAMMP1MMP3 | |
| SCHEMBL799217 | 0.72 | TP53 (0.45) | TP53ALDH1A1LMNAMMP1MMP3 | |
| SCHEMBL799197 | 0.72 | TP53 (0.45) | TP53ALDH1A1LMNAMMP1MMP3 | |
| SCHEMBL13968266 | 0.71 | PIK3C3 (0.32) | PIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022086986-A1 | TREATMENT OF HEMATOLOGICAL MALIGNANCIES WITH INHIBITORS OF MENIN | KURA ONCOLOGY, INC. (US) | 2022-04-28 | — | — | WO | disclosed |
| WO-2019060365-A1 | SUBSTITUTED INHIBITORS OF MENIN-MLL AND METHODS OF USE | KURA ONCOLOGY, INC. (US) | 2019-03-28 | — | — | WO | disclosed |