SCHEMBL20848983

SCHEMBL20848983

N#Cc1cccc(-n2c3ccc(C(F)(F)F)cc3c3cc(C(F)(F)F)ccc32)c1-c1cc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)ccc1-n1c2ccc(C(F)(F)F)cc2c2cc(C(F)(F)F)ccc21

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.34
AR P10275 4/20 0.33
TSHR P16473 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
ALDH1A1 P00352 1/20 0.33
GAA P10253 1/20 0.33
GRIN1 Q05586 1/20 0.33
GRIN2B Q13224 1/20 0.33
ICMT O60725 1/20 0.32
CYP11B1 P15538 1/20 0.32
CYP11B2 P19099 1/20 0.32
GABRA1 P14867 1/20 0.32
GABRG2 P18507 1/20 0.32
GABRB3 P28472 1/20 0.32
GABRA5 P31644 1/20 0.32
GABRA3 P34903 1/20 0.32
ALOX5AP P20292 1/20 0.31
FEN1 P39748 1/20 0.31
CTSS P25774 1/20 0.31
RXRA P19793 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20848990 0.96 KIF11 (0.33) KDM4EARTSHRSMN1; SMN2ALDH1A1
SCHEMBL20849272 0.96 AR (0.34) KDM4EARALDH1A1GAAGRIN1
SCHEMBL20849294 0.95 ICMT (0.34) KDM4EARTSHRSMN1; SMN2ALDH1A1
SCHEMBL22985550 0.93 ALOX5AP (0.39) KDM4EARTSHRSMN1; SMN2ALDH1A1
SCHEMBL21399301 0.92 KIF11 (0.33) KDM4EARTSHRSMN1; SMN2ALDH1A1
SCHEMBL20849274 0.92 ICMT (0.32) KDM4EARALDH1A1GAAGRIN1
SCHEMBL20848984 0.92 TACR1 (0.35) KDM4EARGRIN1GRIN2BCYP11B1
SCHEMBL20849298 0.92 TACR1 (0.35) KDM4EARSMN1; SMN2ALDH1A1GAA
SCHEMBL20849297 0.92 PPARG (0.33) ARTSHRSMN1; SMN2ICMTGABRA1
SCHEMBL20849046 0.91 TACR1 (0.38) KDM4EARICMTGABRA1GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10978646-B2 Organic molecules for use in optoelectronic devices CYNORA GMBH (DE) 2021-04-13 US disclosed
US-20190097141-A1 ORGANIC MOLECULES FOR USE IN OPTOELECTRONIC DEVICES SAMSUNG DISPLAY CO., LTD. (KR) 2019-03-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10978646-B2 Organic molecules for use in optoelectronic devices OCIAD2, OCIAD1, POU2F1 KDM4E 1952/4885AR 3706/4885TSHR 3496/4885
US-20190097141-A1 ORGANIC MOLECULES FOR USE IN OPTOELECTRONIC DEVICES OCIAD2, OCIAD1, POU2F1 KDM4E 1952/4885AR 3706/4885TSHR 3496/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.