⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7813247 | 0.73 | — | — | |
| SCHEMBL2778898 | 0.72 | RAB9A (0.46) | — | |
| SCHEMBL9088969 | 0.71 | — | — | |
| SCHEMBL514393 | 0.71 | — | — | |
| SCHEMBL208499 | 0.69 | — | — | |
| SCHEMBL18587846 | 0.68 | — | — | |
| SCHEMBL9641370 | 0.67 | — | — | |
| SCHEMBL304772 | 0.67 | BCHE (0.33) | — | |
| SCHEMBL514694 | 0.67 | — | — | |
| SCHEMBL8213811 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 276 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2787995-B1 | SPIROTHIENOPYRAN-PIPERIDINE DERIVATIVES AS ORL-1 RECEPTOR ANTAGONISTS FOR THEIR USE IN THE TREATMENT OF ALCOHOL DEPENDENCE AND ABUSE | LILLY CO ELI (US) | 2016-08-17 | — | — | EP | claimed |
| US-9371335-B2 | Spirothienopyran-piperidine derivatives as ORL-1 receptor antagonists for their use in the treatment of alcohol dependence and abuse | ELI LILLY AND COMPANY (US) | 2016-06-21 | — | — | US | claimed |
| US-20140309251-A1 | SPIROTHIENOPYRAN-PIPERIDINE DERIVATIVES AS ORL-1 RECEPTOR ANTAGONISTS FOR THEIR USE IN THE TREATMENT OF ALCOHOL DEPENDENCE AND ABUSE | ELI LILLY AND COMPANY (US) | 2014-10-16 | — | — | US | claimed |
| EP-2787995-A1 | SPIROTHIENOPYRAN- PIPERIDINE DERIVATIVES AS ORL-1 RECEPTOR ANTAGONISTS FOR THEIR USE IN THE TREATMENT OF ALCOHOL DEPENDENCE AND ABUSE | Eli Lilly and Company (US) | 2014-10-15 | — | — | EP | claimed |
| WO-2014022143-A1 | ORL-1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ANXIETY | ELI LILLY AND COMPANY (US) | 2014-02-06 | — | — | WO | claimed |
| EP-2501703-B1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2013-09-18 | — | — | EP | claimed |
| EP-2501704-B1 | Spiropiperidine compounds as oral-1 receptor antagagonisten | LILLY CO ELI (US) | 2013-09-18 | — | — | EP | claimed |
| WO-2013085781-A1 | SPIROTHIENOPYRAN- PIPERIDINE DERIVATIVES AS ORL-1 RECEPTOR ANTAGONISTS FOR THEIR USE IN THE TREATMENT OF ALCOHOL DEPENDENCE AND ABUSE | ELI LILLY AND COMPANY (US) | 2013-06-13 | — | — | WO | claimed |
| US-20130005730-A1 | NOVEL 1,3-OXAZOLIDINE COMPOUNDS AND THEIR USE AS RENIN INHIBITORS | MEDIVIR AB (SE) | 2013-01-03 | — | — | US | claimed |
| US-20120301426-A1 | ALKANOYLAMINO BENZAMIDE ANILINE HDAC INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2012-11-29 | — | — | US | claimed |
| EP-0055562-B1 | CEPHALOSPORIN DERIVATIVES | ICI PHARMA (FR) | 1986-02-12 | — | — | EP | claimed |
| EP-0158922-A2 | Tetrahydrofuran-2-ylmethylamines | BAYER AG (DE) | 1985-10-23 | — | — | EP | claimed |
| EP-0131793-A2 | 5-Aminomethyl-1,3-oxathiolanes | BAYER AG (DE) | 1985-01-23 | — | — | EP | claimed |
| EP-0055099-B1 | PENICILLIN DERIVATIVES | ICI PHARMA (FR) | 1984-10-24 | — | — | EP | claimed |
| EP-0075434-A2 | Cephalosporins, their preparation and their pharmaceutical compositions | ICI PHARMA (FR) | 1983-03-30 | — | — | EP | claimed |
| EP-0072608-A2 | Process for the preparation of cephalosporin derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-02-23 | — | — | EP | claimed |
| EP-0071370-A2 | Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them | ICI PHARMA (FR) | 1983-02-09 | — | — | EP | claimed |
| EP-0055562-A2 | Cephalosporin derivatives | ICI PHARMA (FR) | 1982-07-07 | — | — | EP | claimed |
| EP-0055099-A1 | Penicillin derivatives | ICI PHARMA (FR) | 1982-06-30 | — | — | EP | claimed |
| US-4241211-A | TOXIC AGENTS FOR CHEMICAL WARFARE | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1980-12-23 | — | — | US | claimed |