Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GNRHR | P30968 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13343117 | 0.82 | KDM4E (0.40) | GNRHRADRA2AADRA1AKDM4ESLC6A2 | |
| SCHEMBL20855722 | 0.81 | ADRA2A (0.40) | GNRHRADRA2AADRA1AKDM4ESLC6A2 | |
| SCHEMBL14983853 | 0.81 | SLC6A2 (0.40) | GNRHRADRA2AADRA1AKDM4ESLC6A2 | |
| SCHEMBL30963569 | 0.80 | CA1 (0.46) | SMN1; SMN2 | |
| SCHEMBL20855412 | 0.80 | SCN4A (0.42) | ADRA2AADRA1AKDM4ECYP2D6MEN1 | |
| SCHEMBL20855556 | 0.80 | KDM4E (0.43) | SMN1; SMN2ADRA2AADRA1AKDM4ECYP2D6 | |
| SCHEMBL20855410 | 0.80 | SCN4A (0.42) | ADRA2AADRA1AKDM4ECYP2D6MEN1 | |
| SCHEMBL28491946 | 0.80 | PDCD1LG2 (0.39) | GNRHRADRA2AADRA1AKDM4ESLC6A2 | |
| SCHEMBL28491947 | 0.80 | PDCD1LG2 (0.39) | GNRHRADRA2AADRA1AKDM4ESLC6A2 | |
| SCHEMBL30152526 | 0.80 | PDCD1LG2 (0.39) | GNRHRADRA2AADRA1AKDM4ESLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019063748-A1 | ROR-GAMMA INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-04-04 | — | — | WO | disclosed |
| WO-2019063748-A1 | ROR-GAMMA INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-04-04 | — | — | WO | disclosed |