Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.59 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.59 |
| ▸ | CCNB2 | O95067 | 7/20 | 0.40 |
| ▸ | CDK1 | P06493 | 7/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 7/20 | 0.40 |
| ▸ | PI4KA | P42356 | 2/20 | 0.40 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.40 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | ADA | P00813 | 4/20 | 0.35 |
| ▸ | PDE2A | O00408 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22459061 | 0.83 | PI4KA (0.45) | ADORA2AADORA2BADORA1CCNB2CDK1 | |
| SCHEMBL23867105 | 0.76 | ADORA2A (0.69) | ADORA2AADORA2BADORA1CCNB2CDK1 | |
| SCHEMBL233401 | 0.75 | ADORA2A (1.00) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL240049 | 0.75 | ADORA2A (1.00) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL22946798 | 0.75 | ADORA2A (0.68) | ADORA2AADORA2BADORA1CCNB2CDK1 | |
| SCHEMBL4572183 | 0.75 | ADORA2A (1.00) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL20857248 | 0.74 | ADORA1 (0.51) | ADORA2AADORA1CDK1PI4KAPI4K2B | |
| SCHEMBL22458547 | 0.73 | PI4KA (0.58) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL21943154 | 0.72 | ADORA2A (0.64) | ADORA2AADORA2BADORA1CCNB2CDK1 | |
| SCHEMBL19661692 | 0.72 | ADORA2A (0.64) | ADORA2AADORA2BADORA1CCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10246480-B2 | Compounds for the treatment of cancer | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2019-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10246480-B2 | Compounds for the treatment of cancer | TP53, MYC, CDC73 | ADORA2A 3844/4885ADORA2B 4297/4885ADORA1 4601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.