Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.64 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.64 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.64 |
| ▸ | CCNB2 | O95067 | 10/20 | 0.56 |
| ▸ | CDK1 | P06493 | 10/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 10/20 | 0.56 |
| ▸ | CCNB3 | Q8WWL7 | 10/20 | 0.56 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.55 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE1A | P54750 | 1/20 | 0.44 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL756298 | 0.84 | YTHDC1 (0.62) | ADORA2AADORA2BADORA1CCNB2CDK1 | |
| SCHEMBL21943153 | 0.83 | CDK1 (0.61) | ADORA2AADORA2BADORA1CCNB2CDK1 | |
| SCHEMBL21128138 | 0.81 | YTHDC1 (0.58) | ADORA2AADORA2BADORA1CCNB2CDK1 | |
| SCHEMBL21316709 | 0.80 | CDK1 (0.81) | ADORA2AADORA2BADORA1CCNB2CDK1 | |
| SCHEMBL23867105 | 0.80 | ADORA2A (0.69) | ADORA2AADORA2BADORA1CCNB2CDK1 | |
| SCHEMBL240049 | 0.78 | ADORA2A (1.00) | ADORA2AADORA2BADORA1PDE4APDE4B | |
| SCHEMBL4572183 | 0.78 | ADORA2A (1.00) | ADORA2AADORA2BADORA1PDE4APDE4B | |
| SCHEMBL22946798 | 0.78 | ADORA2A (0.68) | ADORA2AADORA2BADORA1CCNB2CDK1 | |
| SCHEMBL233401 | 0.78 | ADORA2A (1.00) | ADORA2AADORA2BADORA1PDE4APDE4B | |
| SCHEMBL26354839 | 0.77 | CDK1 (0.72) | ADORA2AADORA2BADORA1CCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10010550-B2 | Inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2018-07-03 | — | — | US | disclosed |
| US-20170340633-A1 | INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170340633-A1 | INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | PIK3CD, PIK3CA, PIK3CG | ADORA2A 3432/4885ADORA2B 3586/4885ADORA1 2913/4885 |
| US-10010550-B2 | Inhibitors of human phosphatidylinositol 3-kinase delta | PIK3CD, PIK3CA, PIK3CG | ADORA2A 3432/4885ADORA2B 3586/4885ADORA1 2913/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.