Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2086574 | 1.00 | KMT2A (0.43) | KMT2ASMN1; SMN2MEN1MAPTALDH1A1 | |
| SCHEMBL2086573 | 1.00 | KMT2A (0.43) | KMT2ASMN1; SMN2MEN1MAPTALDH1A1 | |
| SCHEMBL2087636 | 0.84 | PTGDR2 (0.48) | KMT2AMEN1MAPTALDH1A1KDM4E | |
| SCHEMBL2087639 | 0.84 | PTGDR2 (0.48) | KMT2AMEN1MAPTALDH1A1KDM4E | |
| SCHEMBL2088024 | 0.83 | ALDH1A1 (0.49) | KMT2ASMN1; SMN2MEN1MAPTALDH1A1 | |
| SCHEMBL2088022 | 0.83 | ALDH1A1 (0.49) | KMT2ASMN1; SMN2MEN1MAPTALDH1A1 | |
| SCHEMBL2087961 | 0.79 | PTGDR2 (0.47) | KMT2ASMN1; SMN2MEN1MAPTALDH1A1 | |
| SCHEMBL2087962 | 0.79 | PTGDR2 (0.47) | KMT2ASMN1; SMN2MEN1MAPTALDH1A1 | |
| SCHEMBL2088336 | 0.79 | PTGDR2 (0.48) | MAPTALDH1A1KDM4ELMNAAPP | |
| SCHEMBL2090192 | 0.79 | PTGDR2 (0.38) | SMN1; SMN2MAPTALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897788-B2 | Indol-1-yl-acetic acid derivatives | ACTELION PHARMACEUTICAL LTD. (CH) | 2011-03-01 | — | — | US | disclosed |
| US-20070208004-A1 | Indol-1-yl-acetic acid derivatives | ACTELION PHARMACEUTICALS, LTD. (CH) | 2007-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070208004-A1 | Indol-1-yl-acetic acid derivatives | IDO1, IDO2, AANAT | KMT2A 1575/4885SMN1; SMN2 3745/4885MEN1 2045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.