Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 17/20 | 0.75 |
| ▸ | CCNH | P51946 | 15/20 | 0.75 |
| ▸ | CDK1 | P06493 | 3/20 | 0.63 |
| ▸ | CDK13 | Q14004 | 2/20 | 0.63 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.63 |
| ▸ | CDK2 | P24941 | 2/20 | 0.63 |
| ▸ | CDK9 | P50750 | 2/20 | 0.63 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.63 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.63 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.63 |
| ▸ | CCNK | O75909 | 1/20 | 0.63 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.63 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.63 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.63 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.63 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.63 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.63 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | CDK8 | P49336 | 1/20 | 0.56 |
| ▸ | HPGDS | O60760 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29855866 | 0.91 | CDK7 (0.75) | CDK7CCNHCDK1CDK13CDK12 | |
| SCHEMBL20288972 | 0.87 | CDK7 (0.75) | CDK7CCNHCDK1CDK13CDK12 | |
| SCHEMBL20289038 | 0.86 | CDK7 (0.73) | CDK7CCNHCDK1CDK13CDK12 | |
| SCHEMBL18313430 | 0.86 | CDK7 (1.00) | CDK7CCNHCDK1CDK13CDK12 | |
| SCHEMBL18078640 | 0.85 | EGFR (0.68) | CDK7CCNHCDK1CDK13CDK12 | |
| SCHEMBL20416128 | 0.84 | CDK7 (0.65) | CDK7CCNHCDK1CDK13CDK12 | |
| SCHEMBL20289272 | 0.84 | CDK7 (0.78) | CDK7CCNHCDK1CDK13CDK12 | |
| SCHEMBL22143288 | 0.83 | CDK7 (0.75) | CDK7CCNHCDK1CDK13CDK12 | |
| SCHEMBL22143273 | 0.83 | CDK7 (0.74) | CDK7CCNHCDK1CDK13CDK12 | |
| SCHEMBL22143294 | 0.81 | CDK7 (0.76) | CDK7CCNHCDK1CDK13CDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787436-B2 | Inhibitors of cyclin-dependent kinase 7 (CDK7) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-09-29 | — | — | US | disclosed |
| US-20190100511-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190100511-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | CDK7, CDK9, CDK6 | CDK7 1/4885CCNH 32/4885CDK1 5/4885 |
| US-10787436-B2 | Inhibitors of cyclin-dependent kinase 7 (CDK7) | CDK7, CDK9, CDK6 | CDK7 1/4885CCNH 32/4885CDK1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.