Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL23453806 | 0.98 | SMN1; SMN2 (0.54) | SMN1; SMN2CHRM1POLBKDM4EALDH1A1 | |
| SCHEMBL855052 | 0.89 | SMN1; SMN2 (0.67) | SMN1; SMN2KDM4EALDH1A1HSD11B1S1PR5 | |
| Hydrochloric Acid SCHEMBL6997154 | 0.87 | SMN1; SMN2 (0.64) | SMN1; SMN2KDM4EALDH1A1HSD11B1S1PR5 | |
| SCHEMBL24528929 | 0.86 | SMN1; SMN2 (0.55) | SMN1; SMN2CHRM1POLBKDM4EKMT2A | |
| Acetic Acid SCHEMBL7372307 | 0.85 | SMN1; SMN2 (0.62) | SMN1; SMN2KDM4EALDH1A1HSD11B1S1PR5 | |
| SCHEMBL9370255 | 0.81 | SMN1; SMN2 (0.58) | SMN1; SMN2KDM4EALDH1A1HSD11B1S1PR5 | |
| SCHEMBL23251841 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2CHRM1POLBKDM4EKMT2A | |
| SCHEMBL25689233 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2CHRM1POLBKDM4EKMT2A | |
| SCHEMBL1978680 | 0.80 | ALDH1A1 (0.44) | SMN1; SMN2CHRM1KDM4EALDH1A1KMT2A | |
| SCHEMBL11919050 | 0.80 | SMN1; SMN2 (0.53) | SMN1; SMN2CHRM1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897603-B2 | Selected CGRP-antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-03-01 | — | — | US | disclosed |
| US-7378411-B2 | Substituted thienopyrimidinones as a mitotic kinesin inhibitor | MERCK & CO., INC. (US) | 2008-05-27 | — | — | US | disclosed |