Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 11/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20867851 | 0.99 | PLA2G7 (0.54) | PLA2G7CYP3A4CYP2D6PTGDR2CXCR2 | |
| SCHEMBL20868001 | 0.88 | PLA2G7 (0.71) | PLA2G7CYP3A4CYP2D6CXCR2 | |
| SCHEMBL20855983 | 0.87 | PLA2G7 (0.73) | PLA2G7CYP3A4CYP2D6 | |
| SCHEMBL20868287 | 0.84 | PLA2G7 (0.40) | PLA2G7PTGDR2CXCR2KDM4EMEN1 | |
| SCHEMBL24200493 | 0.83 | PLA2G7 (0.50) | PLA2G7CYP3A4CYP2D6KDM4EHTT | |
| SCHEMBL3542421 | 0.81 | PLA2G7 (0.72) | PLA2G7CYP3A4CYP2D6PTGDR2 | |
| SCHEMBL30579901 | 0.81 | PLA2G7 (0.53) | PLA2G7CYP3A4CYP2D6 | |
| SCHEMBL26340188 | 0.77 | PLA2G7 (0.73) | PLA2G7CYP3A4CYP2D6 | |
| SCHEMBL20856595 | 0.77 | PLA2G7 (0.80) | PLA2G7CYP3A4CYP2D6 | |
| SCHEMBL26338749 | 0.76 | PLA2G7 (0.72) | PLA2G7CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230302162-A1 | RADIOLABELED DARAPLADIB AND ANALOGS THEREOF AND THEIR USE AS IMAGING COMPOUNDS | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2023-09-28 | — | — | US | disclosed |
| US-20230302162-A1 | RADIOLABELED DARAPLADIB AND ANALOGS THEREOF AND THEIR USE AS IMAGING COMPOUNDS | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2023-09-28 | — | — | US | disclosed |
| US-11583596-B2 | Radiolabeled Darapladib and analogs thereof and their use as imaging compounds | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2023-02-21 | — | — | US | disclosed |
| EP-3687980-B1 | RADIOLABELED DARAPLADIB, ANALOGS THEREOF AND THEIR USE AS IMAGING COMPOUNDS | INST NAT SANTE RECH MED (FR) | 2022-01-19 | — | — | EP | disclosed |
| US-20200276337-A1 | RADIOLABELED DARAPLADIB AND ANALOGS THEREOF AND THEIR USE AS IMAGING COMPOUNDS | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2020-09-03 | — | — | US | disclosed |
| WO-2019063634-A1 | RADIOLABELED DARAPLADIB AND ANALOGS THEREOF AND THEIR USE AS IMAGING COMPOUNDS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2019-04-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11583596-B2 | Radiolabeled Darapladib and analogs thereof and their use as imaging compounds | PLA2G4B, PLA2G1B, PLA2G12B | PLA2G7 30/4885CYP3A4 4428/4885CYP2D6 3516/4885 |
| US-20230302162-A1 | RADIOLABELED DARAPLADIB AND ANALOGS THEREOF AND THEIR USE AS IMAGING COMPOUNDS | PLA2G4B, PLA2G1B, PLA2G12B | PLA2G7 30/4885CYP3A4 4428/4885CYP2D6 3516/4885 |
| US-20200276337-A1 | RADIOLABELED DARAPLADIB AND ANALOGS THEREOF AND THEIR USE AS IMAGING COMPOUNDS | PLA2G4B, PLA2G1B, PLA2G12B | PLA2G7 30/4885CYP3A4 4428/4885CYP2D6 3516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.