SCHEMBL20868252

SCHEMBL20868252

CCCNC(=O)C1COC1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.53
CHRNB4 P30926 1/20 0.53
CHRNA3 P32297 1/20 0.53
CHRNA7 P36544 1/20 0.53
CHRNA4 P43681 1/20 0.53
BCHE P06276 3/20 0.47
NAAA Q02083 1/20 0.44
GNAI3 P08754 1/20 0.41
GNAO1 P09471 1/20 0.41
GNAI1 P63096 1/20 0.41
KDM4E B2RXH2 2/20 0.41
HPGD P15428 2/20 0.41
HSD17B10 Q99714 1/20 0.41
EPHX1 P07099 2/20 0.39
ALDH1A1 P00352 1/20 0.39
MMP1 P03956 1/20 0.38
MMP2 P08253 1/20 0.38
MMP3 P08254 1/20 0.38
MMP9 P14780 1/20 0.38
EPHX2 P34913 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7817651 0.92 CHRNB2 (0.50) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL20928257 0.85 CHRNB2 (0.47) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL23169304 0.83
SCHEMBL15862853 0.81 POLB (0.42) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL103494 0.80
SCHEMBL6361465 0.80 NAAA (0.50) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL2502163 0.77
SCHEMBL8140520 0.77 NAAA (0.70) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL6361129 0.77 CHRNB2 (0.70) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL1768014 0.77 NAAA (0.65) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3694506-B1 NOVEL SUBSTITUTED PHENYLOXETANE AND PHENYLTETRAHYDROFURAN COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS MERCK SHARP & DOHME LLC (US) 2023-08-02 EP claimed
WO-2019062435-A1 USE OF TRIAZOLOPYRIMIDINE, TRIAZOLOPYRIDINE COMPOUNDS AND COMPOSITION THEREOF FOR TREATING PRC2-MEDIATED DISEASES 中国科学院上海药物研究所 2019-04-04 WO disclosed