Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.52 |
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20870024 | 0.86 | TP53 (0.50) | KDM4EALDH1A1MAPTGAAPOLB | |
| SCHEMBL29944917 | 0.84 | KDM4E (0.53) | KDM4EALDH1A1MAPTGAAPOLB | |
| SCHEMBL24334609 | 0.84 | KDM4E (0.53) | KDM4EALDH1A1MAPTGAAPOLB | |
| SCHEMBL20869962 | 0.83 | KMT2A (0.50) | KDM4EALDH1A1MAPTGAAPOLB | |
| SCHEMBL20869961 | 0.82 | TP53 (0.51) | KDM4EALDH1A1MAPTGAAPOLB | |
| SCHEMBL23633375 | 0.74 | MAT2A (0.49) | KDM4EALDH1A1MAPTGAAPOLB | |
| SCHEMBL16783126 | 0.69 | RXFP1 (0.55) | KDM4EALDH1A1MAPTGAAPOLB | |
| SCHEMBL3859996 | 0.69 | CNR2 (0.60) | KDM4EALDH1A1MAPTGAAPOLB | |
| SCHEMBL16783112 | 0.69 | RXFP1 (0.48) | KDM4EALDH1A1MAPTGAAPOLB | |
| SCHEMBL16783147 | 0.68 | KDM4E (0.67) | KDM4EALDH1A1MAPTGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3687529-B1 | POTENT ANTIVIRAL PYRIDINE-CONTAINING COMPOUNDS | UNIV CALIFORNIA (US) | 2023-07-12 | — | — | EP | disclosed |
| US-11180498-B2 | Substituted pyrrolo[2,3-b]pyridines, pyrazolo[3,4-d]pyrimidines and [1,2,3]triazolo[4,5-b]pyridines as potent antivirals | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-11-23 | — | — | US | disclosed |
| US-20200223842-A1 | POTENT ANTIVIRAL PYRIDINE-CONTAINING COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-07-16 | — | — | US | disclosed |
| WO-2019067623-A1 | POTENT ANTIVIRAL PYRIDINE-CONTAINING COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-04-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11180498-B2 | Substituted pyrrolo[2,3-b]pyridines, pyrazolo[3,4-d]pyrimidines and [1,2,3]triazolo[4,5-b]pyridines as potent antivirals | PNPO, TYMS, TYMP | KDM4E 1843/4885ALDH1A1 2521/4885MAPT 3504/4885 |
| US-20200223842-A1 | POTENT ANTIVIRAL PYRIDINE-CONTAINING COMPOUNDS | ZC3HAV1, MAVS, SARS1 | KDM4E 692/4885ALDH1A1 1563/4885MAPT 3612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.