Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 5/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.46 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22493890 | 0.86 | RAB9A (0.62) | ROCK2NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL22493893 | 0.85 | LMNA (0.59) | TMPRSS2NAMPTROCK2L3MBTL3NPC1 | |
| SCHEMBL23253874 | 0.82 | PIK3CA (0.52) | TMPRSS2NAMPTROCK2L3MBTL3NPC1 | |
| SCHEMBL20873112 | 0.82 | NAMPT (0.49) | TMPRSS2NAMPTL3MBTL3NPC1RAB9A | |
| SCHEMBL20873108 | 0.80 | GRM4 (0.56) | TMPRSS2NAMPTNPC1RAB9AKDM4E | |
| SCHEMBL22493880 | 0.79 | TMPRSS2 (0.57) | TMPRSS2NAMPTL3MBTL3NPC1RAB9A | |
| SCHEMBL20873105 | 0.79 | RAB9A (0.66) | ROCK2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL20873100 | 0.79 | F2R (0.47) | TMPRSS2NAMPTROCK2L3MBTL3NPC1 | |
| SCHEMBL20873126 | 0.78 | KCNK3 (0.54) | TMPRSS2NAMPTL3MBTL3NPC1RAB9A | |
| SCHEMBL20873124 | 0.77 | LMNA (0.52) | TMPRSS2NAMPTL3MBTL3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464289-B1 | ULTRA-POTENT VINCA ALKALOIDS: ADDED MOLECULAR COMPLEXITY FURTHER DISRUPTS THE TUBULIN DIMER-DIMER INTERFACE | SCRIPPS RESEARCH INST (US) | 2021-04-21 | — | — | EP | disclosed |
| EP-3464289-A1 | ULTRA-POTENT VINA ALKALOIDS: ADDED MOLECULAR COMPLEXITY FURTHER DISRUPTS THE TUBLIN DIMER-DIMER INTERFACE | The Scripps Research Institute (US) | 2019-04-10 | — | — | EP | disclosed |