SCHEMBL20873286

SCHEMBL20873286

OC1O[C@H](CN2CCN(c3ccc(Cl)cc3)CC2)[C@H](O)[C@H](O)[C@H]1O

nearest known ligand 0.45

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ DRD4 P21917 5/20 0.45
▸ DRD2 P14416 3/20 0.45
▸ SMN1; SMN2 Q16637 2/20 0.43
▸ GFER P55789 1/20 0.43
▸ DRD5 P21918 1/20 0.43
▸ MAPT P10636 3/20 0.43
▸ HSD11B1 P28845 1/20 0.42
▸ KDM4E B2RXH2 3/20 0.42
▸ GAA P10253 2/20 0.42
▸ ALDH1A1 P00352 2/20 0.42
▸ MAPK1 P28482 1/20 0.41
▸ DRD3 P35462 1/20 0.41
▸ HTR1A P08908 2/20 0.40
▸ KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20873246 0.88 DRD4 (0.44) DRD4DRD2SMN1; SMN2GFERDRD5
SCHEMBL20873314 0.78 MAPT (0.48) DRD4SMN1; SMN2MAPTKDM4EGAA
SCHEMBL24138061 0.78 MAPT (0.48) DRD4SMN1; SMN2MAPTKDM4EGAA
SCHEMBL21148624 0.74 SLC5A2 (0.43) DRD4DRD2SMN1; SMN2DRD5MAPT
SCHEMBL21148625 0.74 SLC5A2 (0.43) DRD4DRD2SMN1; SMN2DRD5MAPT
SCHEMBL20873281 0.74 SLC5A2 (0.43) DRD4DRD2SMN1; SMN2DRD5MAPT
SCHEMBL21112919 0.72 MEN1 (0.54) SMN1; SMN2GFERMAPTALDH1A1KMT2A
Hydrochloric Acid SCHEMBL10992760 0.70 DRD4 (0.54) DRD4DRD2MAPTKDM4EGAA
SCHEMBL14067276 0.69 DRD4 (0.61) DRD4SMN1; SMN2GFERDRD5MAPT
SCHEMBL21148820 0.69 DRD4 (0.41) DRD4DRD2DRD5MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210401946-A1 CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN SANOFI (FR) 2021-12-30 — — US disclosed
US-20210401946-A1 CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN SANOFI (FR) 2021-12-30 — — US disclosed
US-20210401947-A1 CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN SANOFI (FR) 2021-12-30 — — US disclosed
US-20210401947-A1 CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN SANOFI (FR) 2021-12-30 — — US disclosed
US-11090364-B2 Conjugates of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein SANOFI (FR) 2021-08-17 — — US disclosed
US-11090364-B2 Conjugates of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein SANOFI (FR) 2021-08-17 — — US disclosed
US-20190209656-A1 CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN SANOFI (FR) 2019-07-11 — — US disclosed
US-20190209656-A1 CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN SANOFI (FR) 2019-07-11 — — US disclosed
EP-3463480-A1 CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN Sanofi (FR) 2019-04-10 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11090364-B2 Conjugates of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein GPR119, SLC2A8, SLC2A4 DRD4 4226/4885DRD2 4570/4885SMN1; SMN2 4049/4885
US-20190209656-A1 CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN GPR119, SLC2A8, SLC2A4 DRD4 4226/4885DRD2 4570/4885SMN1; SMN2 4049/4885
US-20210401946-A1 CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN GPR119, SLC2A8, SLC2A4 DRD4 4226/4885DRD2 4570/4885SMN1; SMN2 4049/4885
US-20210401947-A1 CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN GPR119, SLC2A8, SLC2A4 DRD4 4226/4885DRD2 4570/4885SMN1; SMN2 4049/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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