Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | KDM6A | O15550 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KDM5C | P41229 | 1/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.36 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 2/20 | 0.35 |
| ▸ | CCND1 | P24385 | 2/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 4/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20886862 | 0.79 | KDM4E (0.41) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 | |
| SCHEMBL12586402 | 0.75 | CA2 (0.35) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 | |
| SCHEMBL23356590 | 0.73 | KDM4E (0.38) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 | |
| SCHEMBL30609643 | 0.72 | KDM4E (0.48) | KDM4EALDH1A1MAPTRXFP1NQO2 | |
| SCHEMBL1138076 | 0.72 | KDM4E (0.48) | KDM4EALDH1A1MAPTRXFP1NQO2 | |
| SCHEMBL2070041 | 0.72 | SLC2A1 (0.36) | GRM2CNR2CNR1 | |
| SCHEMBL3577290 | 0.70 | TAF1 (0.41) | KDM4ECDK4CCND1CCNE2CCNE1 | |
| SCHEMBL23356601 | 0.70 | CDK4 (0.42) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 | |
| SCHEMBL2071263 | 0.70 | SMN1; SMN2 (0.47) | KDM4EALDH1A1GRM2 | |
| SCHEMBL28513044 | 0.69 | BRPF1 (0.35) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019070742-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK 1) INHIBITOR COMPOUNDS | SIDECAR THERAPEUTICS, INC. (US) | 2019-04-11 | — | — | WO | disclosed |
| WO-2019070742-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK 1) INHIBITOR COMPOUNDS | SIDECAR THERAPEUTICS, INC. (US) | 2019-04-11 | — | — | WO | disclosed |