SCHEMBL20877490

SCHEMBL20877490

CC(C)(C)OC(=O)Nc1nc(Cl)c(C(C)(C)C)s1

nearest known ligand 0.48

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
LCK P06239 12/20 0.48
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
PI4KB Q9UBF8 1/20 0.40
ATR Q13535 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20883048 0.86 LCK (0.45) LCKCA1CA2PI4KBATR
SCHEMBL13801888 0.81 DYRK1A (0.44)
SCHEMBL16753973 0.81 LCK (0.53) LCKCA1CA2PI4KBATR
SCHEMBL25403792 0.81 LCK (0.53) LCKCA1CA2PI4KBATR
SCHEMBL25261549 0.81 LCK (0.53) LCKCA1CA2PI4KBATR
Hydrochloric Acid SCHEMBL25403795 0.79 LCK (0.52) LCKCA1CA2PI4KBATR
SCHEMBL1268366 0.79 LCK (0.46) LCKCA1CA2PI4KBATR
SCHEMBL25295310 0.77 LCK (0.53) LCKCA1CA2PI4KB
SCHEMBL1563222 0.76 LCK (0.48) LCKCA1CA2PI4KB
SCHEMBL28816640 0.75 LCK (0.47) LCKCA1CA2PI4KBATR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111148743-B Inhibition of ubiquitin-specific peptidase 30 福马治疗有限公司 2023-12-15 CN disclosed
EP-3692028-B1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 30 FORMA THERAPEUTICS INC (US) 2023-04-26 EP disclosed
US-20220185806-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 30 FORMA THERAPEUTICS, INC. 2022-06-16 US disclosed
US-11247987-B2 Inhibiting ubiquitin specific peptidase 30 FORMA THERAPEUTICS, INC. (US) 2022-02-15 US disclosed
US-11247987-B2 Inhibiting ubiquitin specific peptidase 30 FORMA THERAPEUTICS, INC. (US) 2022-02-15 US disclosed
US-20200317658-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 30 FORMA THERAPEUTICS, INC. 2020-10-08 US disclosed
US-20200317658-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 30 FORMA THERAPEUTICS, INC. 2020-10-08 US disclosed
EP-3692028-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 30 Forma Therapeutics, Inc. (US) 2020-08-12 EP disclosed
CN-111148743-A Inhibition of ubiquitin-specific peptidase 30 福马治疗有限公司 2020-05-12 CN disclosed
WO-2019071073-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 30 FORMA THERAPEUTICS, INC. (US) 2019-04-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220185806-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 30 USP30, UCHL1, UCHL3 LCK 3555/4885CA1 2800/4885CA2 3861/4885
US-11247987-B2 Inhibiting ubiquitin specific peptidase 30 USP30, UCHL1, UCHL3 LCK 3965/4885CA1 2102/4885CA2 3640/4885
US-20200317658-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 30 USP30, UCHL1, UCHL3 LCK 3555/4885CA1 2800/4885CA2 3861/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.