Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLG | P54098 | 2/20 | 0.64 |
| ▸ | PNP | P00491 | 6/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | POLA1 | P09884 | 1/20 | 0.55 |
| ▸ | TGM2 | P21980 | 1/20 | 0.49 |
| ▸ | HPRT1 | P00492 | 7/20 | 0.49 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.48 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.48 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.48 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.48 |
| ▸ | KRAS | P01116 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20879512 | 0.92 | POLG (0.61) | POLGPNPPOLBPOLA1TGM2 | |
| Dideoxy Guanosine Triphosphate SCHEMBL25712486 | 0.86 | POLB (0.60) | POLGPNPPOLBPOLA1TGM2 | |
| Dideoxy Guanosine Triphosphate SCHEMBL80109 | 0.86 | POLB (0.60) | POLGPNPPOLBPOLA1TGM2 | |
| Dideoxy Guanosine Triphosphate SCHEMBL25720613 | 0.86 | POLB (0.60) | POLGPNPPOLBPOLA1TGM2 | |
| SCHEMBL18095578 | 0.86 | POLB (0.60) | POLGPNPPOLBPOLA1TGM2 | |
| Dideoxy Guanosine Triphosphate SCHEMBL24370775 | 0.86 | POLB (0.60) | POLGPNPPOLBPOLA1TGM2 | |
| SCHEMBL4968018 | 0.85 | POLB (0.61) | POLGPNPPOLBPOLA1TGM2 | |
| SCHEMBL21234661 | 0.85 | POLG (0.62) | POLGPNPPOLBPOLA1HPRT1 | |
| SCHEMBL24785330 | 0.84 | POLG (0.56) | POLGPNPPOLBPOLA1TGM2 | |
| SCHEMBL19662102 | 0.84 | POLB (0.66) | POLGPNPPOLBPOLA1TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466959-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | Janssen BioPharma, Inc. (US) | 2019-04-10 | — | — | EP | disclosed |