Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 7/20 | 0.55 |
| ▸ | P2RX1 | P51575 | 4/20 | 0.55 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.55 |
| ▸ | P2RX4 | Q99571 | 6/20 | 0.53 |
| ▸ | TRPM2 | O94759 | 2/20 | 0.53 |
| ▸ | P2RY1 | P47900 | 4/20 | 0.52 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.49 |
| ▸ | MACROD2 | A1Z1Q3 | 1/20 | 0.49 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.49 |
| ▸ | MACROD1 | Q9BQ69 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20058653 | 0.89 | P2RY1 (0.47) | P2RX3P2RX1P2RX2P2RX4P2RY1 | |
| SCHEMBL18840499 | 0.86 | P2RX3 (0.57) | P2RX3P2RX1P2RX2P2RX4TRPM2 | |
| SCHEMBL21029886 | 0.86 | POLB (0.61) | P2RX3P2RX1P2RX2P2RX4TRPM2 | |
| SCHEMBL22887211 | 0.85 | P2RX3 (0.55) | P2RX3P2RX1P2RX2P2RX4TRPM2 | |
| SCHEMBL23584298 | 0.84 | P2RX3 (0.66) | P2RX3P2RX1P2RX2P2RX4TRPM2 | |
| SCHEMBL16024812 | 0.84 | P2RX3 (0.66) | P2RX3P2RX1P2RX2P2RX4TRPM2 | |
| SCHEMBL16203364 | 0.84 | P2RX3 (0.66) | P2RX3P2RX1P2RX2P2RX4TRPM2 | |
| SCHEMBL24081967 | 0.82 | P2RX1 (0.49) | P2RX3P2RX1P2RX2P2RX4TRPM2 | |
| SCHEMBL23761036 | 0.82 | P2RX3 (0.49) | P2RX3P2RX1P2RX2P2RX4TRPM2 | |
| SCHEMBL20059105 | 0.82 | P2RX1 (0.40) | P2RX3P2RX1P2RX2P2RX4P2RY1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466959-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | Janssen BioPharma, Inc. (US) | 2019-04-10 | — | — | EP | disclosed |