Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 19/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.83 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28941700 | 1.00 | STING1 (1.00) | STING1CYP3A4ENPP1 | |
| SCHEMBL29403883 | 1.00 | STING1 (1.00) | STING1CYP3A4ENPP1 | |
| SCHEMBL29080456 | 0.94 | STING1 (0.88) | STING1CYP3A4 | |
| SCHEMBL29791220 | 0.94 | STING1 (0.88) | STING1CYP3A4 | |
| SCHEMBL26772071 | 0.94 | STING1 (0.88) | STING1CYP3A4 | |
| SCHEMBL23077592 | 0.93 | STING1 (0.86) | STING1CYP3A4 | |
| SCHEMBL23077481 | 0.93 | STING1 (0.86) | STING1CYP3A4 | |
| SCHEMBL21685655 | 0.92 | STING1 (0.85) | STING1CYP3A4 | |
| SCHEMBL21158087 | 0.91 | STING1 (0.84) | STING1CYP3A4 | |
| SCHEMBL19437697 | 0.91 | STING1 (0.87) | STING1CYP3A4ENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3440072-B1 | HETEROCYCLIC AMIDES USEFUL AS PROTEIN MODULATORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-01-29 | — | — | EP | claimed |
| WO-2023215740-A1 | IMMUNOMODULATORY ANTIBODY-DRUG CONJUGATES | SEAGEN INC. (US) | 2023-11-09 | — | — | WO | disclosed |
| CN-111417630-B | Modulators of interferon gene stimulating factor (STING) | 葛兰素史克知识产权开发有限公司 | 2023-06-06 | — | — | CN | disclosed |
| US-11377440-B2 | Modulators of stimulator of interferon genes (STING) | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2022-07-05 | — | — | US | disclosed |
| CN-114585623-A | Bis [ N- ((5-carbamoyl) -1H-benzo [ d ] imidazol-2-yl) pyrazole-5-carboxamide ] derivatives and related compounds as STING (interferon gene stimulator) agonists for the treatment of cancer | 梅尔莎纳医疗公司 | 2022-06-03 | — | — | CN | disclosed |
| US-20220119379-A1 | IMMUNOMODULATOR | HITGEN INC. (CN) | 2022-04-21 | — | — | US | disclosed |
| US-11155567-B2 | Sting agonist compounds and methods of use | MERSANA THERAPEUTICS, INC. (US) | 2021-10-26 | — | — | US | disclosed |
| US-10975287-B2 | Heterocyclic amides useful as protein modulators | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED | 2021-04-13 | — | — | US | disclosed |
| US-20210032269-A1 | STING AGONIST COMPOUNDS AND METHODS OF USE | MERSANA THERAPEUTICS, INC. | 2021-02-04 | — | — | US | disclosed |
| US-20200325126-A1 | HETEROCYCLIC AMIDES USEFUL AS PROTEIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-10-15 | — | — | US | disclosed |
| US-20200291001-A1 | MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-09-17 | — | — | US | disclosed |
| WO-2020156363-A1 | IMMUNOMODULATOR | 成都先导药物开发股份有限公司 | 2020-08-06 | — | — | WO | disclosed |
| WO-2020132566-A1 | STING PYRAZOLE AGONISTS AND USES THEREOF | NIMBUS TITAN, INC. (US) | 2020-06-25 | — | — | WO | disclosed |
| US-20200031825-A1 | HETEROAROMATIC-FUSED IMIDAZOLYL AMIDES, COMPOSITIONS AND USES THEREOF AS STING AGONISTS | TRILLIUM THERAPEUTICS INC. (CA) | 2020-01-30 | — | — | US | disclosed |
| US-20200031825-A1 | HETEROAROMATIC-FUSED IMIDAZOLYL AMIDES, COMPOSITIONS AND USES THEREOF AS STING AGONISTS | TRILLIUM THERAPEUTICS INC. (CA) | 2020-01-30 | — | — | US | disclosed |
| WO-2020010451-A1 | HETEROAROMATIC-FUSED IMIDAZOLYL AMIDES, COMPOSITIONS AND USES THEREOF AS STING AGONISTS | TRILLIUM THERAPEUTICS INC. (CA) | 2020-01-16 | — | — | WO | disclosed |
| WO-2020010451-A1 | HETEROAROMATIC-FUSED IMIDAZOLYL AMIDES, COMPOSITIONS AND USES THEREOF AS STING AGONISTS | TRILLIUM THERAPEUTICS INC. (CA) | 2020-01-16 | — | — | WO | disclosed |
| WO-2019134705-A1 | IMMUNOMODULATOR | 成都先导药物开发股份有限公司 | 2019-07-11 | — | — | WO | disclosed |
| WO-2019069270-A1 | MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200031825-A1 | HETEROAROMATIC-FUSED IMIDAZOLYL AMIDES, COMPOSITIONS AND USES THEREOF AS STING AGONISTS | STING1, MAVS, IRF3 | STING1 1/4885CYP3A4 4386/4885ENPP1 1724/4885 |
| US-20220119379-A1 | IMMUNOMODULATOR | STING1, TLR9, CGAS | STING1 1/4885CYP3A4 4813/4885ENPP1 255/4885 |
| US-11155567-B2 | Sting agonist compounds and methods of use | STING1, IRF3, MAVS | STING1 1/4885CYP3A4 4415/4885ENPP1 1372/4885 |
| US-20200325126-A1 | HETEROCYCLIC AMIDES USEFUL AS PROTEIN MODULATORS | ARGLU1, G3BP1, G3BP2 | STING1 2510/4885CYP3A4 3885/4885ENPP1 3334/4885 |
| US-11377440-B2 | Modulators of stimulator of interferon genes (STING) | STING1, IRF3, IFNAR1 | STING1 1/4885CYP3A4 3948/4885ENPP1 3246/4885 |
| US-10975287-B2 | Heterocyclic amides useful as protein modulators | ARGLU1, G3BP1, G3BP2 | STING1 2510/4885CYP3A4 3885/4885ENPP1 3334/4885 |
| US-20210032269-A1 | STING AGONIST COMPOUNDS AND METHODS OF USE | STING1, IRF3, MAVS | STING1 1/4885CYP3A4 4415/4885ENPP1 1372/4885 |
| US-20200291001-A1 | MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) | STING1, IRF3, IFNAR1 | STING1 1/4885CYP3A4 3948/4885ENPP1 3246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.