Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.79 |
| ▸ | GAA | P10253 | 6/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.77 |
| ▸ | MAPT | P10636 | 5/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.77 |
| ▸ | GFER | P55789 | 3/20 | 0.77 |
| ▸ | HPGD | P15428 | 1/20 | 0.77 |
| ▸ | HTT | P42858 | 3/20 | 0.69 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | TP53 | P04637 | 2/20 | 0.69 |
| ▸ | CASP1 | P29466 | 2/20 | 0.69 |
| ▸ | CASP7 | P55210 | 2/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.69 |
| ▸ | RAB9A | P51151 | 1/20 | 0.69 |
| ▸ | XBP1 | P17861 | 1/20 | 0.67 |
| ▸ | PIM1 | P11309 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20889688 | 0.88 | ALOX5 (0.79) | ALOX5GAAALDH1A1MAPTKDM4E | |
| SCHEMBL20889480 | 0.88 | ALOX5 (0.79) | ALOX5GAAALDH1A1MAPTKDM4E | |
| SCHEMBL20889481 | 0.88 | ALOX5 (0.71) | ALOX5GAAALDH1A1MAPTKDM4E | |
| SCHEMBL20889535 | 0.88 | ALOX5 (0.74) | ALOX5GAAALDH1A1MAPTKDM4E | |
| SCHEMBL20889528 | 0.85 | ALOX5 (0.74) | ALOX5GAAALDH1A1MAPTKDM4E | |
| SCHEMBL20889678 | 0.85 | GAA (0.77) | ALOX5GAAALDH1A1MAPTKDM4E | |
| SCHEMBL20889547 | 0.85 | ALOX5 (0.86) | ALOX5GAAALDH1A1MAPTKDM4E | |
| SCHEMBL20889687 | 0.85 | ALOX5 (0.74) | ALOX5GAAALDH1A1MAPTKDM4E | |
| SCHEMBL20889739 | 0.85 | ALOX5 (0.67) | ALOX5GAAALDH1A1MAPTKDM4E | |
| SCHEMBL20889477 | 0.85 | ALOX5 (0.73) | ALOX5GAAALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11530209-B2 | Small molecule inhibition of transcription factor SALL4 and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-12-20 | — | — | US | disclosed |
| US-20200317664-A1 | SMALL MOLECULE INHIBITION OF TRANSCRIPTION FACTOR SALL4 AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-10-08 | — | — | US | disclosed |
| WO-2019070943-A1 | SMALL MOLECULE INHIBITION OF TRANSCRIPTION FACTOR SALL4 AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11530209-B2 | Small molecule inhibition of transcription factor SALL4 and uses thereof | SALL4, GLI2, TCF4 | ALOX5 3823/4885GAA 3761/4885ALDH1A1 1038/4885 |
| US-20200317664-A1 | SMALL MOLECULE INHIBITION OF TRANSCRIPTION FACTOR SALL4 AND USES THEREOF | SALL4, GLI2, TCF4 | ALOX5 3823/4885GAA 3761/4885ALDH1A1 1038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.