Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SALL4 | Q9UJQ4 | 12/20 | 1.00 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.67 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20889566 | 0.94 | SALL4 (1.00) | SALL4TRIM24TRIM33ALDH1A1GAA | |
| SCHEMBL20889515 | 0.87 | SALL4 (1.00) | SALL4TRIM24TRIM33ALDH1A1GAA | |
| SCHEMBL20889494 | 0.82 | SALL4 (1.00) | SALL4TRIM24ALDH1A1GAAMAPT | |
| SCHEMBL20889499 | 0.80 | SALL4 (1.00) | SALL4TRIM24TRIM33BRD4 | |
| SCHEMBL20889287 | 0.79 | SALL4 (0.65) | SALL4TRIM24TRIM33ALDH1A1GAA | |
| SCHEMBL20889512 | 0.78 | SALL4 (1.00) | SALL4TRIM24TRIM33L3MBTL1BRD4 | |
| SCHEMBL20889721 | 0.76 | SALL4 (0.78) | SALL4TRIM24TRIM33BRD4 | |
| SCHEMBL20889720 | 0.76 | SALL4 (0.78) | SALL4TRIM24TRIM33GAAMAPT | |
| SCHEMBL20889571 | 0.75 | SALL4 (0.79) | SALL4TRIM24TRIM33GAAMAPT | |
| SCHEMBL2986458 | 0.75 | ALOX5 (0.70) | SALL4TRIM24TRIM33ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11530209-B2 | Small molecule inhibition of transcription factor SALL4 and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-12-20 | — | — | US | disclosed |
| US-20200317664-A1 | SMALL MOLECULE INHIBITION OF TRANSCRIPTION FACTOR SALL4 AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-10-08 | — | — | US | disclosed |
| WO-2019070943-A1 | SMALL MOLECULE INHIBITION OF TRANSCRIPTION FACTOR SALL4 AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11530209-B2 | Small molecule inhibition of transcription factor SALL4 and uses thereof | SALL4, GLI2, TCF4 | SALL4 1/4885TRIM24 203/4885TRIM33 564/4885 |
| US-20200317664-A1 | SMALL MOLECULE INHIBITION OF TRANSCRIPTION FACTOR SALL4 AND USES THEREOF | SALL4, GLI2, TCF4 | SALL4 1/4885TRIM24 203/4885TRIM33 564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.